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636 results

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Page 1
Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.
Kusakabe K, Ide N, Daigo Y, Itoh T, Yamamoto T, Hashizume H, Nozu K, Yoshida H, Tadano G, Tagashira S, Higashino K, Okano Y, Sato Y, Inoue M, Iguchi M, Kanazawa T, Ishioka Y, Dohi K, Kido Y, Sakamoto S, Ando S, Maeda M, Higaki M, Baba Y, Nakamura Y. Kusakabe K, et al. Among authors: hashizume h. J Med Chem. 2015 Feb 26;58(4):1760-75. doi: 10.1021/jm501599u. Epub 2015 Feb 10. J Med Chem. 2015. PMID: 25625617
Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125).
Kusakabe K, Ide N, Daigo Y, Tachibana Y, Itoh T, Yamamoto T, Hashizume H, Hato Y, Higashino K, Okano Y, Sato Y, Inoue M, Iguchi M, Kanazawa T, Ishioka Y, Dohi K, Kido Y, Sakamoto S, Yasuo K, Maeda M, Higaki M, Ueda K, Yoshizawa H, Baba Y, Shiota T, Murai H, Nakamura Y. Kusakabe K, et al. Among authors: hashizume h. J Med Chem. 2013 Jun 13;56(11):4343-56. doi: 10.1021/jm4000215. Epub 2013 May 24. J Med Chem. 2013. PMID: 23634759
Discovery of S-777469: an orally available CB2 agonist as an antipruritic agent.
Odan M, Ishizuka N, Hiramatsu Y, Inagaki M, Hashizume H, Fujii Y, Mitsumori S, Morioka Y, Soga M, Deguchi M, Yasui K, Arimura A. Odan M, et al. Among authors: hashizume h. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2803-6. doi: 10.1016/j.bmcl.2012.02.072. Epub 2012 Mar 3. Bioorg Med Chem Lett. 2012. PMID: 22444677
Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 1. Bicyclo[2.2.1]heptane derivatives.
Mitsumori S, Tsuri T, Honma T, Hiramatsu Y, Okada T, Hashizume H, Inagaki M, Arimura A, Yasui K, Asanuma F, Kishino J, Ohtani M. Mitsumori S, et al. Among authors: hashizume h. J Med Chem. 2003 Jun 5;46(12):2436-45. doi: 10.1021/jm020517g. J Med Chem. 2003. PMID: 12773047
Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 2. 6,6-Dimethylbicyclo[3.1.1]heptane derivatives.
Mitsumori S, Tsuri T, Honma T, Hiramatsu Y, Okada T, Hashizume H, Kida S, Inagaki M, Arimura A, Yasui K, Asanuma F, Kishino J, Ohtani M. Mitsumori S, et al. Among authors: hashizume h. J Med Chem. 2003 Jun 5;46(12):2446-55. doi: 10.1021/jm0205189. J Med Chem. 2003. PMID: 12773048
Pyrrolidine inhibitors of human cytosolic phospholipase A(2).
Seno K, Okuno T, Nishi K, Murakami Y, Watanabe F, Matsuura T, Wada M, Fujii Y, Yamada M, Ogawa T, Okada T, Hashizume H, Kii M, Hara S, Hagishita S, Nakamoto S, Yamada K, Chikazawa Y, Ueno M, Teshirogi I, Ono T, Ohtani M. Seno K, et al. Among authors: hashizume h. J Med Chem. 2000 Mar 23;43(6):1041-4. doi: 10.1021/jm9905155. J Med Chem. 2000. PMID: 10737736 No abstract available.
Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent.
Odan M, Ishizuka N, Hiramatsu Y, Inagaki M, Hashizume H, Fujii Y, Mitsumori S, Morioka Y, Soga M, Deguchi M, Yasui K, Arimura A. Odan M, et al. Among authors: hashizume h. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2898-901. doi: 10.1016/j.bmcl.2012.02.050. Epub 2012 Feb 23. Bioorg Med Chem Lett. 2012. PMID: 22421019
636 results