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Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion.
Shibue K, Yamane S, Harada N, Hamasaki A, Suzuki K, Joo E, Iwasaki K, Nasteska D, Harada T, Hayashi Y, Adachi Y, Owada Y, Takayanagi R, Inagaki N. Shibue K, et al. Among authors: suzuki k. Am J Physiol Endocrinol Metab. 2015 Apr 1;308(7):E583-91. doi: 10.1152/ajpendo.00543.2014. Epub 2015 Jan 27. Am J Physiol Endocrinol Metab. 2015. PMID: 25628425 Free article.
Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity.
Suzuki K, Harada N, Yamane S, Nakamura Y, Sasaki K, Nasteska D, Joo E, Shibue K, Harada T, Hamasaki A, Toyoda K, Nagashima K, Inagaki N. Suzuki K, et al. J Biol Chem. 2013 Jan 18;288(3):1929-38. doi: 10.1074/jbc.M112.423137. Epub 2012 Nov 28. J Biol Chem. 2013. PMID: 23192339 Free PMC article.
KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state.
Ogata H, Seino Y, Harada N, Iida A, Suzuki K, Izumoto T, Ishikawa K, Uenishi E, Ozaki N, Hayashi Y, Miki T, Inagaki N, Tsunekawa S, Hamada Y, Seino S, Oiso Y. Ogata H, et al. Among authors: suzuki k. J Endocrinol. 2014 Aug;222(2):191-200. doi: 10.1530/JOE-14-0161. Epub 2014 Jun 2. J Endocrinol. 2014. PMID: 24891433
Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.
Iwasaki K, Harada N, Sasaki K, Yamane S, Iida K, Suzuki K, Hamasaki A, Nasteska D, Shibue K, Joo E, Harada T, Hashimoto T, Asakawa Y, Hirasawa A, Inagaki N. Iwasaki K, et al. Among authors: suzuki k. Endocrinology. 2015 Mar;156(3):837-46. doi: 10.1210/en.2014-1653. Epub 2014 Dec 23. Endocrinology. 2015. PMID: 25535828
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