Alvarez Sanchez R - Search Results

1

Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach.

Ratni H, Rogers-Evans M, Bissantz C, Grundschober C, Moreau JL, Schuler F, Fischer H, Alvarez Sanchez R, Schnider P. Ratni H, et al. Among authors: alvarez sanchez r. J Med Chem. 2015 Mar 12;58(5):2275-89. doi: 10.1021/jm501745f. Epub 2015 Feb 18. J Med Chem. 2015. PMID: 25654260

2

Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists.

Martin RE, Mohr P, Maerki HP, Guba W, Kuratli C, Gavelle O, Binggeli A, Bendels S, Alvarez-Sánchez R, Alker A, Polonchuk L, Christ AD. Martin RE, et al. Among authors: alvarez sanchez r. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6106-13. doi: 10.1016/j.bmcl.2009.09.024. Epub 2009 Sep 12. Bioorg Med Chem Lett. 2009. PMID: 19786348

3

Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.

Hebeisen P, Haap W, Kuhn B, Mohr P, Wessel HP, Zutter U, Kirchner S, Ruf A, Benz J, Joseph C, Alvarez-Sánchez R, Gubler M, Schott B, Benardeau A, Tozzo E, Kitas E. Hebeisen P, et al. Among authors: alvarez sanchez r. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3237-42. doi: 10.1016/j.bmcl.2011.04.044. Epub 2011 Apr 20. Bioorg Med Chem Lett. 2011. PMID: 21550236

4

2-Phenoxy-nicotinamides are potent agonists at the bile acid receptor GPBAR1 (TGR5).

Martin RE, Bissantz C, Gavelle O, Kuratli C, Dehmlow H, Richter HG, Obst Sander U, Erickson SD, Kim K, Pietranico-Cole SL, Alvarez-Sánchez R, Ullmer C. Martin RE, et al. Among authors: alvarez sanchez r. ChemMedChem. 2013 Apr;8(4):569-76. doi: 10.1002/cmdc.201200474. Epub 2012 Dec 7. ChemMedChem. 2013. PMID: 23225346

5

PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation.

Caruso A, Alvarez-Sánchez R, Hillebrecht A, Poirier A, Schuler F, Lavé T, Funk C, Belli S. Caruso A, et al. Among authors: alvarez sanchez r. Biochem Pharmacol. 2013 Jun 1;85(11):1684-99. doi: 10.1016/j.bcp.2013.02.021. Epub 2013 Feb 27. Biochem Pharmacol. 2013. PMID: 23454189

6

Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists.

Dehmlow H, Alvarez Sánchez R, Bachmann S, Bissantz C, Bliss F, Conde-Knape K, Graf M, Martin RE, Obst Sander U, Raab S, Richter HG, Sewing S, Sprecher U, Ullmer C, Mattei P. Dehmlow H, et al. Among authors: alvarez sanchez r. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4627-32. doi: 10.1016/j.bmcl.2013.06.017. Epub 2013 Jun 19. Bioorg Med Chem Lett. 2013. PMID: 23831134

7

3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors.

Pinard E, Alberati D, Alvarez-Sanchez R, Brom V, Burner S, Fischer H, Hauser N, Kolczewski S, Lengyel J, Mory R, Saladin C, Schulz-Gasch T, Stalder H. Pinard E, et al. Among authors: alvarez sanchez r. ACS Med Chem Lett. 2014 Feb 4;5(4):428-33. doi: 10.1021/ml500005m. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900853 Free PMC article.

8

Minimizing DILI risk in drug discovery - A screening tool for drug candidates.

Schadt S, Simon S, Kustermann S, Boess F, McGinnis C, Brink A, Lieven R, Fowler S, Youdim K, Ullah M, Marschmann M, Zihlmann C, Siegrist YM, Cascais AC, Di Lenarda E, Durr E, Schaub N, Ang X, Starke V, Singer T, Alvarez-Sanchez R, Roth AB, Schuler F, Funk C. Schadt S, et al. Among authors: alvarez sanchez r. Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):429-37. doi: 10.1016/j.tiv.2015.09.019. Epub 2015 Sep 25. Toxicol In Vitro. 2015. PMID: 26407524

9

Estimation of Drug Binding to Brain Tissue: Methodology and in Vivo Application of a Distribution Assay in Brain Polar Lipids.

Belli S, Assmus F, Wagner B, Honer M, Fischer H, Schuler F, Alvarez-Sánchez R. Belli S, et al. Among authors: alvarez sanchez r. Mol Pharm. 2015 Dec 7;12(12):4529-41. doi: 10.1021/acs.molpharmaceut.5b00717. Epub 2015 Nov 23. Mol Pharm. 2015. PMID: 26560069

10

Development of a Unified Dissolution and Precipitation Model and Its Use for the Prediction of Oral Drug Absorption.

Jakubiak P, Wagner B, Grimm HP, Petrig-Schaffland J, Schuler F, Alvarez-Sánchez R. Jakubiak P, et al. Among authors: alvarez sanchez r. Mol Pharm. 2016 Feb 1;13(2):586-98. doi: 10.1021/acs.molpharmaceut.5b00808. Epub 2016 Jan 5. Mol Pharm. 2016. PMID: 26674605

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