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Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming.
Rupanagudi KV, Kulkarni OP, Lichtnekert J, Darisipudi MN, Mulay SR, Schott B, Gruner S, Haap W, Hartmann G, Anders HJ. Rupanagudi KV, et al. Among authors: haap w. Ann Rheum Dis. 2015 Feb;74(2):452-63. doi: 10.1136/annrheumdis-2013-203717. Epub 2013 Dec 3. Ann Rheum Dis. 2015. PMID: 24300027
Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.
Kumar Vr S, Darisipudi MN, Steiger S, Devarapu SK, Tato M, Kukarni OP, Mulay SR, Thomasova D, Popper B, Demleitner J, Zuchtriegel G, Reichel C, Cohen CD, Lindenmeyer MT, Liapis H, Moll S, Reid E, Stitt AW, Schott B, Gruner S, Haap W, Ebeling M, Hartmann G, Anders HJ. Kumar Vr S, et al. Among authors: haap w. J Am Soc Nephrol. 2016 Jun;27(6):1635-49. doi: 10.1681/ASN.2015020208. Epub 2015 Nov 13. J Am Soc Nephrol. 2016. PMID: 26567242 Free PMC article.
Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate.
Anselm L, Banner DW, Benz J, Zbinden KG, Himber J, Hilpert H, Huber W, Kuhn B, Mary JL, Otteneder MB, Panday N, Ricklin F, Stahl M, Thomi S, Haap W. Anselm L, et al. Among authors: haap w. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5313-9. doi: 10.1016/j.bmcl.2010.06.126. Epub 2010 Jul 1. Bioorg Med Chem Lett. 2010. PMID: 20650636
Systematic investigation of halogen bonding in protein-ligand interactions.
Hardegger LA, Kuhn B, Spinnler B, Anselm L, Ecabert R, Stihle M, Gsell B, Thoma R, Diez J, Benz J, Plancher JM, Hartmann G, Banner DW, Haap W, Diederich F. Hardegger LA, et al. Among authors: haap w. Angew Chem Int Ed Engl. 2011 Jan 3;50(1):314-8. doi: 10.1002/anie.201006781. Angew Chem Int Ed Engl. 2011. PMID: 21184410 No abstract available.
33 results