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Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart.
Burmeister BT, Taglieri DM, Wang L, Carnegie GK. Burmeister BT, et al. Among authors: carnegie gk. J Biol Chem. 2012 Nov 23;287(48):40535-46. doi: 10.1074/jbc.M112.385641. Epub 2012 Oct 8. J Biol Chem. 2012. PMID: 23045525 Free PMC article.
AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy.
Spindler MJ, Burmeister BT, Huang Y, Hsiao EC, Salomonis N, Scott MJ, Srivastava D, Carnegie GK, Conklin BR. Spindler MJ, et al. Among authors: carnegie gk. PLoS One. 2013 Apr 26;8(4):e62705. doi: 10.1371/journal.pone.0062705. Print 2013. PLoS One. 2013. Retraction in: PLoS One. 2023 Dec 12;18(12):e0296004. doi: 10.1371/journal.pone.0296004 PMID: 23658642 Free PMC article. Retracted.
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