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The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis.
Miyazaki M, Miyazaki K, Chen S, Chandra V, Wagatsuma K, Agata Y, Rodewald HR, Saito R, Chang AN, Varki N, Kawamoto H, Murre C. Miyazaki M, et al. Among authors: chang an. Genes Dev. 2015 Feb 15;29(4):409-25. doi: 10.1101/gad.255331.114. Genes Dev. 2015. PMID: 25691468 Free PMC article.
Id3 Orchestrates Germinal Center B Cell Development.
Chen S, Miyazaki M, Chandra V, Fisch KM, Chang AN, Murre C. Chen S, et al. Among authors: chang an. Mol Cell Biol. 2016 Sep 26;36(20):2543-52. doi: 10.1128/MCB.00150-16. Print 2016 Oct 15. Mol Cell Biol. 2016. PMID: 27457619 Free PMC article.
Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification.
Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, Bui JD, Chang AN, Yates JR 3rd, Goldrath AW, Overkleeft HS, Ovaa H, Chang JT. Widjaja CE, et al. Among authors: chang an, chang jt. J Clin Invest. 2017 Oct 2;127(10):3609-3623. doi: 10.1172/JCI90895. Epub 2017 Aug 28. J Clin Invest. 2017. PMID: 28846070 Free PMC article.
Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.
Shen JP, Zhao D, Sasik R, Luebeck J, Birmingham A, Bojorquez-Gomez A, Licon K, Klepper K, Pekin D, Beckett AN, Sanchez KS, Thomas A, Kuo CC, Du D, Roguev A, Lewis NE, Chang AN, Kreisberg JF, Krogan N, Qi L, Ideker T, Mali P. Shen JP, et al. Among authors: chang an. Nat Methods. 2017 Jun;14(6):573-576. doi: 10.1038/nmeth.4225. Epub 2017 Mar 20. Nat Methods. 2017. PMID: 28319113 Free PMC article.
211 results