Jenkins MR - Search Results

1

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells.

Davenport AJ, Jenkins MR, Cross RS, Yong CS, Prince HM, Ritchie DS, Trapani JA, Kershaw MH, Darcy PK, Neeson PJ. Davenport AJ, et al. Among authors: jenkins mr. Cancer Immunol Res. 2015 May;3(5):483-94. doi: 10.1158/2326-6066.CIR-15-0048. Epub 2015 Feb 24. Cancer Immunol Res. 2015. PMID: 25711536

2

Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.

Waterhouse NJ, Sutton VR, Sedelies KA, Ciccone A, Jenkins M, Turner SJ, Bird PI, Trapani JA. Waterhouse NJ, et al. J Cell Biol. 2006 Apr 10;173(1):133-44. doi: 10.1083/jcb.200510072. J Cell Biol. 2006. PMID: 16606695 Free PMC article.

3

Addition of a prominent epitope affects influenza A virus-specific CD8+ T cell immunodominance hierarchies when antigen is limiting.

Jenkins MR, Webby R, Doherty PC, Turner SJ. Jenkins MR, et al. J Immunol. 2006 Sep 1;177(5):2917-25. doi: 10.4049/jimmunol.177.5.2917. J Immunol. 2006. PMID: 16920927

4

Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice.

Jenkins MR, Trapani JA, Doherty PC, Turner SJ. Jenkins MR, et al. Viral Immunol. 2008 Sep;21(3):341-6. doi: 10.1089/vim.2008.0036. Viral Immunol. 2008. PMID: 18788942

5

Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing.

Jenkins MR, La Gruta NL, Doherty PC, Trapani JA, Turner SJ, Waterhouse NJ. Jenkins MR, et al. Cell Death Differ. 2009 Apr;16(4):537-42. doi: 10.1038/cdd.2008.176. Epub 2009 Jan 9. Cell Death Differ. 2009. PMID: 19136939

6

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack.

Lopez JA, Susanto O, Jenkins MR, Lukoyanova N, Sutton VR, Law RH, Johnston A, Bird CH, Bird PI, Whisstock JC, Trapani JA, Saibil HR, Voskoboinik I. Lopez JA, et al. Among authors: jenkins mr. Blood. 2013 Apr 4;121(14):2659-68. doi: 10.1182/blood-2012-07-446146. Epub 2013 Feb 1. Blood. 2013. PMID: 23377437 Free article.

7

Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.

Lopez JA, Jenkins MR, Rudd-Schmidt JA, Brennan AJ, Danne JC, Mannering SI, Trapani JA, Voskoboinik I. Lopez JA, et al. Among authors: jenkins mr. J Immunol. 2013 Sep 1;191(5):2328-34. doi: 10.4049/jimmunol.1301205. Epub 2013 Jul 24. J Immunol. 2013. PMID: 23885110

8

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.

Jenkins MR, Rudd-Schmidt JA, Lopez JA, Ramsbottom KM, Mannering SI, Andrews DM, Voskoboinik I, Trapani JA. Jenkins MR, et al. J Exp Med. 2015 Mar 9;212(3):307-17. doi: 10.1084/jem.20140964. Epub 2015 Mar 2. J Exp Med. 2015. PMID: 25732304 Free PMC article.

9

Perforin-dependent cytotoxicity: 'Kiss of death' or prolonged embrace with darker elocation-idnseque11es?

Trapani JA, Voskoboinik I, Jenkins MR. Trapani JA, et al. Among authors: jenkins mr. Oncoimmunology. 2015 Apr 14;4(9):e1036215. doi: 10.1080/2162402X.2015.1036215. eCollection 2015 Sep. Oncoimmunology. 2015. PMID: 26405605 Free PMC article.

10

CAR-T cells are serial killers.

Davenport AJ, Jenkins MR, Ritchie DS, Prince HM, Trapani JA, Kershaw MH, Darcy PK, Neeson PJ. Davenport AJ, et al. Among authors: jenkins mr. Oncoimmunology. 2015 Jun 1;4(12):e1053684. doi: 10.1080/2162402X.2015.1053684. eCollection 2015 Dec. Oncoimmunology. 2015. PMID: 26587330 Free PMC article.

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