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Page 1
Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption.
Rothenberger MK, Keele BF, Wietgrefe SW, Fletcher CV, Beilman GJ, Chipman JG, Khoruts A, Estes JD, Anderson J, Callisto SP, Schmidt TE, Thorkelson A, Reilly C, Perkey K, Reimann TG, Utay NS, Nganou Makamdop K, Stevenson M, Douek DC, Haase AT, Schacker TW. Rothenberger MK, et al. Among authors: thorkelson a. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1126-34. doi: 10.1073/pnas.1414926112. Epub 2015 Feb 23. Proc Natl Acad Sci U S A. 2015. PMID: 25713386 Free PMC article.
Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues.
Fletcher CV, Staskus K, Wietgrefe SW, Rothenberger M, Reilly C, Chipman JG, Beilman GJ, Khoruts A, Thorkelson A, Schmidt TE, Anderson J, Perkey K, Stevenson M, Perelson AS, Douek DC, Haase AT, Schacker TW. Fletcher CV, et al. Among authors: thorkelson a. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2307-12. doi: 10.1073/pnas.1318249111. Epub 2014 Jan 27. Proc Natl Acad Sci U S A. 2014. PMID: 24469825 Free PMC article.
Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions.
Sanchez JL, Hunt PW, Reilly CS, Hatano H, Beilman GJ, Khoruts A, Jasurda JS, Somsouk M, Thorkelson A, Russ S, Anderson J, Deeks SG, Schacker TW. Sanchez JL, et al. Among authors: thorkelson a. J Infect Dis. 2015 Apr 1;211(7):1068-75. doi: 10.1093/infdis/jiu586. Epub 2014 Oct 24. J Infect Dis. 2015. PMID: 25344521 Free PMC article.
Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial.
Miller JS, Davis ZB, Helgeson E, Reilly C, Thorkelson A, Anderson J, Lima NS, Jorstad S, Hart GT, Lee JH, Safrit JT, Wong H, Cooley S, Gharu L, Chung H, Soon-Shiong P, Dobrowolski C, Fletcher CV, Karn J, Douek DC, Schacker TW. Miller JS, et al. Among authors: thorkelson a. Nat Med. 2022 Feb;28(2):392-400. doi: 10.1038/s41591-021-01651-9. Epub 2022 Jan 31. Nat Med. 2022. PMID: 35102335 Clinical Trial.
Conflicting evidence for HIV enrichment in CD32+ CD4 T cells.
Pérez L, Anderson J, Chipman J, Thorkelson A, Chun TW, Moir S, Haase AT, Douek DC, Schacker TW, Boritz EA. Pérez L, et al. Among authors: thorkelson a. Nature. 2018 Sep;561(7723):E9-E16. doi: 10.1038/s41586-018-0493-4. Epub 2018 Sep 19. Nature. 2018. PMID: 30232423 Free PMC article. No abstract available.
Safety and Virologic Impact of Haploidentical NK Cells Plus Interleukin 2 or N-803 in HIV Infection.
Miller JS, Rhein J, Davis ZB, Cooley S, McKenna D, Anderson J, Escandón K, Wieking G, Reichel J, Thorkelson A, Jorstad S, Safrit JT, Soon-Shiong P, Beilman GJ, Chipman JG, Schacker TW. Miller JS, et al. Among authors: thorkelson a. J Infect Dis. 2024 May 15;229(5):1256-1265. doi: 10.1093/infdis/jiad578. J Infect Dis. 2024. PMID: 38207119 Clinical Trial.