Wightman M - Search Results

1

Targeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling.

Brewer A, Zhao JF, Fasimoye R, Shpiro N, Macartney TJ, Wood NT, Wightman M, Alessi DR, Sapkota GP. Brewer A, et al. Among authors: wightman m. iScience. 2024 Jul 5;27(8):110423. doi: 10.1016/j.isci.2024.110423. eCollection 2024 Aug 16. iScience. 2024. PMID: 39104417 Free PMC article.

2

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system.

Raimi OG, Ojha H, Ehses K, Dederer V, Lange SM, Rivera CP, Deegan TD, Chen Y, Wightman M, Toth R, Labib KPM, Mathea S, Ranson N, Fernández-Busnadiego R, Muqit MMK. Raimi OG, et al. Among authors: wightman m. Sci Adv. 2024 Jun 7;10(23):eadn7191. doi: 10.1126/sciadv.adn7191. Epub 2024 Jun 7. Sci Adv. 2024. PMID: 38848361 Free PMC article.

3

Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B.

Pal P, Taylor M, Lam PY, Tonelli F, Hecht CA, Lis P, Nirujogi RS, Phung TK, Yeshaw WM, Jaimon E, Fasimoye R, Dickie EA, Wightman M, Macartney T, Pfeffer SR, Alessi DR. Pal P, et al. Among authors: wightman m. Sci Adv. 2023 Dec 15;9(50):eadj1205. doi: 10.1126/sciadv.adj1205. Epub 2023 Dec 13. Sci Adv. 2023. PMID: 38091401 Free PMC article.

4

An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation.

Simpson LM, Fulcher LJ, Sathe G, Brewer A, Zhao JF, Squair DR, Crooks J, Wightman M, Wood NT, Gourlay R, Varghese J, Soares RF, Sapkota GP. Simpson LM, et al. Among authors: wightman m. Cell Chem Biol. 2023 Feb 16;30(2):188-202.e6. doi: 10.1016/j.chembiol.2023.01.003. Epub 2023 Jan 30. Cell Chem Biol. 2023. PMID: 36720221 Free article.

5

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

Malik AU, Karapetsas A, Nirujogi RS, Chatterjee D, Phung TK, Wightman M, Gourlay R, Morrice N, Mathea S, Knapp S, Alessi DR. Malik AU, et al. Among authors: wightman m. Biochem J. 2022 Sep 30;479(18):1941-1965. doi: 10.1042/BCJ20220308. Biochem J. 2022. PMID: 36040231 Free PMC article.

6

Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding.

Kalogeropulou AF, Purlyte E, Tonelli F, Lange SM, Wightman M, Prescott AR, Padmanabhan S, Sammler E, Alessi DR. Kalogeropulou AF, et al. Among authors: wightman m. Biochem J. 2022 Sep 16;479(17):1759-1783. doi: 10.1042/BCJ20220161. Biochem J. 2022. PMID: 35950872 Free PMC article.

7

Constraints on the Ecomorphological Convergence of Zooplanktivorous Butterflyfishes.

Hodge JR, Song Y, Wightman MA, Milkey A, Tran B, Štajner A, Roberts AS, Hemingson CR, Wainwright PC, Price SA. Hodge JR, et al. Among authors: wightman ma. Integr Org Biol. 2021 May 13;3(1):obab014. doi: 10.1093/iob/obab014. eCollection 2021. Integr Org Biol. 2021. PMID: 34377941 Free PMC article.

8

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44.

Malik N, Nirujogi RS, Peltier J, Macartney T, Wightman M, Prescott AR, Gourlay R, Trost M, Alessi DR, Karapetsas A. Malik N, et al. Among authors: wightman m. Biochem J. 2019 Oct 30;476(20):3081-3107. doi: 10.1042/BCJ20190608. Biochem J. 2019. PMID: 31665227 Free PMC article.

9

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.

Berndsen K, Lis P, Yeshaw WM, Wawro PS, Nirujogi RS, Wightman M, Macartney T, Dorward M, Knebel A, Tonelli F, Pfeffer SR, Alessi DR. Berndsen K, et al. Among authors: wightman m. Elife. 2019 Oct 30;8:e50416. doi: 10.7554/eLife.50416. Elife. 2019. PMID: 31663853 Free PMC article.

10

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

Purlyte E, Dhekne HS, Sarhan AR, Gomez R, Lis P, Wightman M, Martinez TN, Tonelli F, Pfeffer SR, Alessi DR. Purlyte E, et al. Among authors: wightman m. EMBO J. 2019 Jan 15;38(2):e101237. doi: 10.15252/embj.2018101237. EMBO J. 2019. PMID: 30647193 Free PMC article.

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