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Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.
Moraga I, Wernig G, Wilmes S, Gryshkova V, Richter CP, Hong WJ, Sinha R, Guo F, Fabionar H, Wehrman TS, Krutzik P, Demharter S, Plo I, Weissman IL, Minary P, Majeti R, Constantinescu SN, Piehler J, Garcia KC. Moraga I, et al. Cell. 2015 Mar 12;160(6):1196-208. doi: 10.1016/j.cell.2015.02.011. Epub 2015 Feb 26. Cell. 2015. PMID: 25728669 Free PMC article.
Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.
Junttila IS, Creusot RJ, Moraga I, Bates DL, Wong MT, Alonso MN, Suhoski MM, Lupardus P, Meier-Schellersheim M, Engleman EG, Utz PJ, Fathman CG, Paul WE, Garcia KC. Junttila IS, et al. Among authors: moraga i. Nat Chem Biol. 2012 Dec;8(12):990-8. doi: 10.1038/nchembio.1096. Epub 2012 Oct 28. Nat Chem Biol. 2012. PMID: 23103943 Free PMC article.
Insights into cytokine-receptor interactions from cytokine engineering.
Spangler JB, Moraga I, Mendoza JL, Garcia KC. Spangler JB, et al. Among authors: moraga i. Annu Rev Immunol. 2015;33:139-67. doi: 10.1146/annurev-immunol-032713-120211. Epub 2014 Dec 10. Annu Rev Immunol. 2015. PMID: 25493332 Free PMC article. Review.
Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.
Ho CCM, Chhabra A, Starkl P, Schnorr PJ, Wilmes S, Moraga I, Kwon HS, Gaudenzio N, Sibilano R, Wehrman TS, Gakovic M, Sockolosky JT, Tiffany MR, Ring AM, Piehler J, Weissman IL, Galli SJ, Shizuru JA, Garcia KC. Ho CCM, et al. Among authors: moraga i. Cell. 2017 Mar 9;168(6):1041-1052.e18. doi: 10.1016/j.cell.2017.02.011. Cell. 2017. PMID: 28283060 Free PMC article.
55 results