Howell GR - Search Results

1

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT. Jay TR, et al. Among authors: howell gr. J Exp Med. 2015 Mar 9;212(3):287-95. doi: 10.1084/jem.20142322. Epub 2015 Mar 2. J Exp Med. 2015. PMID: 25732305 Free PMC article.

2

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.

Howell GR, Macalinao DG, Sousa GL, Walden M, Soto I, Kneeland SC, Barbay JM, King BL, Marchant JK, Hibbs M, Stevens B, Barres BA, Clark AF, Libby RT, John SW. Howell GR, et al. J Clin Invest. 2011 Apr;121(4):1429-44. doi: 10.1172/JCI44646. Epub 2011 Mar 7. J Clin Invest. 2011. PMID: 21383504 Free PMC article.

3

Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma.

Howell GR, Soto I, Zhu X, Ryan M, Macalinao DG, Sousa GL, Caddle LB, MacNicoll KH, Barbay JM, Porciatti V, Anderson MG, Smith RS, Clark AF, Libby RT, John SW. Howell GR, et al. J Clin Invest. 2012 Apr;122(4):1246-61. doi: 10.1172/JCI61135. Epub 2012 Mar 19. J Clin Invest. 2012. PMID: 22426214 Free PMC article.

4

Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice.

Howell GR, Soto I, Ryan M, Graham LC, Smith RS, John SW. Howell GR, et al. J Neuroinflammation. 2013 Jun 27;10:76. doi: 10.1186/1742-2094-10-76. J Neuroinflammation. 2013. PMID: 23806181 Free PMC article.

5

Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma.

Williams PA, Howell GR, Barbay JM, Braine CE, Sousa GL, John SW, Morgan JE. Williams PA, et al. Among authors: howell gr. PLoS One. 2013 Aug 19;8(8):e72282. doi: 10.1371/journal.pone.0072282. eCollection 2013. PLoS One. 2013. PMID: 23977271 Free PMC article.

6

Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease.

Jackson HM, Soto I, Graham LC, Carter GW, Howell GR. Jackson HM, et al. Among authors: howell gr. BMC Genomics. 2013 Nov 25;14:831. doi: 10.1186/1471-2164-14-831. BMC Genomics. 2013. PMID: 24274089 Free PMC article.

7

Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma.

Howell GR, MacNicoll KH, Braine CE, Soto I, Macalinao DG, Sousa GL, John SW. Howell GR, et al. Neurobiol Dis. 2014 Nov;71:44-52. doi: 10.1016/j.nbd.2014.07.016. Epub 2014 Aug 15. Neurobiol Dis. 2014. PMID: 25132557 Free PMC article.

8

DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease.

Jackson HM, Onos KD, Pepper KW, Graham LC, Akeson EC, Byers C, Reinholdt LG, Frankel WN, Howell GR. Jackson HM, et al. Among authors: howell gr. PLoS One. 2015 May 1;10(5):e0125897. doi: 10.1371/journal.pone.0125897. eCollection 2015. PLoS One. 2015. PMID: 25933409 Free PMC article.

9

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.

Soto I, Graham LC, Richter HJ, Simeone SN, Radell JE, Grabowska W, Funkhouser WK, Howell MC, Howell GR. Soto I, et al. Among authors: howell mc, howell gr. PLoS Biol. 2015 Oct 29;13(10):e1002279. doi: 10.1371/journal.pbio.1002279. eCollection 2015 Oct. PLoS Biol. 2015. PMID: 26512759 Free PMC article.

10

Toward more predictive genetic mouse models of Alzheimer's disease.

Onos KD, Sukoff Rizzo SJ, Howell GR, Sasner M. Onos KD, et al. Among authors: howell gr. Brain Res Bull. 2016 Apr;122:1-11. doi: 10.1016/j.brainresbull.2015.12.003. Epub 2015 Dec 17. Brain Res Bull. 2016. PMID: 26708939 Free PMC article. Review.

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