Murayama N - Search Results

1

Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).

Uehara S, Uno Y, Inoue T, Murayama N, Shimizu M, Sasaki E, Yamazaki H. Uehara S, et al. Among authors: murayama n. Drug Metab Dispos. 2015 May;43(5):735-42. doi: 10.1124/dmd.115.063594. Epub 2015 Mar 3. Drug Metab Dispos. 2015. PMID: 25735838

2

Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1.

Ozawa S, Ohta K, Miyajima A, Kurebayashi H, Sunouchi M, Shimizu M, Murayama N, Matsumoto Y, Fukuoka M, Ohno Y. Ozawa S, et al. Among authors: murayama n. Xenobiotica. 2000 Oct;30(10):1005-17. doi: 10.1080/00498250050200159. Xenobiotica. 2000. PMID: 11315102

3

Rat cytochrome P450 2C11 in liver microsomes involved in oxidation of anesthetic agent propofol and deactivated by prior treatment with propofol.

Yamazaki H, Shimizu M, Nagashima T, Minoshima M, Murayama N. Yamazaki H, et al. Among authors: murayama n. Drug Metab Dispos. 2006 Nov;34(11):1803-5. doi: 10.1124/dmd.106.011627. Epub 2006 Aug 8. Drug Metab Dispos. 2006. PMID: 16896062

4

Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities.

Shimizu M, Yano H, Nagashima S, Murayama N, Zhang J, Cashman JR, Yamazaki H. Shimizu M, et al. Among authors: murayama n. Drug Metab Dispos. 2007 Mar;35(3):328-30. doi: 10.1124/dmd.106.013094. Epub 2006 Dec 1. Drug Metab Dispos. 2007. PMID: 17142560

5

Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors.

Shimada T, Murayama N, Okada K, Funae Y, Yamazaki H, Guengerich FP. Shimada T, et al. Among authors: murayama n. Chem Res Toxicol. 2007 Mar;20(3):489-96. doi: 10.1021/tx600299p. Epub 2007 Feb 10. Chem Res Toxicol. 2007. PMID: 17291012

6

Missense and nonsense mutations of the flavin-containing monooxygenase 3 gene in a Japanese cohort.

Shimizu M, Tomioka S, Murayama N, Yamazaki H. Shimizu M, et al. Among authors: murayama n. Drug Metab Pharmacokinet. 2007 Feb 25;22(1):61-4. doi: 10.2133/dmpk.22.61. Drug Metab Pharmacokinet. 2007. PMID: 17329912 Free article.

7

Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes.

Murayama N, Imai N, Nakane T, Shimizu M, Yamazaki H. Murayama N, et al. Biochem Pharmacol. 2007 Jun 15;73(12):2020-6. doi: 10.1016/j.bcp.2007.03.012. Epub 2007 Mar 19. Biochem Pharmacol. 2007. PMID: 17433262

8

Involvement of human cytochrome P450 2B6 in the omega- and 4-hydroxylation of the anesthetic agent propofol.

Murayama N, Minoshima M, Shimizu M, Guengerich FP, Yamazaki H. Murayama N, et al. Xenobiotica. 2007 Jul;37(7):717-24. doi: 10.1080/00498250701449431. Xenobiotica. 2007. PMID: 17620218

9

Comparison of kinetic parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A5.

Niwa T, Murayama N, Emoto C, Yamazaki H. Niwa T, et al. Among authors: murayama n. Curr Drug Metab. 2008 Jan;9(1):20-33. doi: 10.2174/138920008783331121. Curr Drug Metab. 2008. PMID: 18220568 Review.

10

Complex mechanism underlying transcriptional control of the haplotyped flavin-containing monooxygenase 3 (FMO3) gene in Japanese: different regulation between mutations in 5'-upstream distal region and common element in proximal region.

Shimizu M, Murayama N, Nagashima S, Fujieda M, Yamazaki H. Shimizu M, et al. Among authors: murayama n. Drug Metab Pharmacokinet. 2008;23(1):54-8. doi: 10.2133/dmpk.23.54. Drug Metab Pharmacokinet. 2008. PMID: 18305374 Free article.

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