Small DS - Search Results

1

A Multidose Study to Examine the Effect of Food on Evacetrapib Exposure at Steady State.

Small DS, Zhang W, Royalty J, Cannady EA, Downs D, Friedrich S, Suico JG. Small DS, et al. J Cardiovasc Pharmacol Ther. 2015 Sep;20(5):483-9. doi: 10.1177/1074248415575153. Epub 2015 Mar 3. J Cardiovasc Pharmacol Ther. 2015. PMID: 25736283 Free PMC article. Clinical Trial.

2

Assessment of the persistence of anacetrapib and evacetrapib concentrations using two pharmacokinetic modeling approaches.

Small DS, Ke AB, Hall SD, Mantlo N, Rotelli M, Friedrich S. Small DS, et al. J Clin Pharmacol. 2015 Jul;55(7):757-67. doi: 10.1002/jcph.472. Epub 2015 Feb 20. J Clin Pharmacol. 2015. PMID: 25651523

3

Absolute bioavailability of evacetrapib in healthy subjects determined by simultaneous administration of oral evacetrapib and intravenous [(13) C8 ]-evacetrapib as a tracer.

Cannady EA, Aburub A, Ward C, Hinds C, Czeskis B, Ruterbories K, Suico JG, Royalty J, Ortega D, Pack BW, Begum SL, Annes WF, Lin Q, Small DS. Cannady EA, et al. Among authors: small ds. J Labelled Comp Radiopharm. 2016 May 30;59(6):238-44. doi: 10.1002/jlcr.3358. Epub 2015 Dec 7. J Labelled Comp Radiopharm. 2016. PMID: 26639670 Free PMC article. Clinical Trial.

4

Effect of hepatic or renal impairment on the pharmacokinetics of evacetrapib.

Small DS, Zhang W, Royalty J, Cannady EA, Downs D, Ortega D, Suico JG. Small DS, et al. Eur J Clin Pharmacol. 2016 May;72(5):563-72. doi: 10.1007/s00228-016-2017-1. Epub 2016 Feb 9. Eur J Clin Pharmacol. 2016. PMID: 26857125 Free PMC article. Clinical Trial.

5

Impact of Increased Gastric pH on the Pharmacokinetics of Evacetrapib in Healthy Subjects.

Small DS, Royalty J, Cannady EA, Hale C, Wang MD, Downs D, Suico JG. Small DS, et al. Pharmacotherapy. 2016 Jul;36(7):749-56. doi: 10.1002/phar.1778. Epub 2016 Jul 8. Pharmacotherapy. 2016. PMID: 27284735 Free PMC article.

6

Evacetrapib: in vitro and clinical disposition, metabolism, excretion, and assessment of drug interaction potential with strong CYP3A and CYP2C8 inhibitors.

Cannady EA, Wang MD, Friedrich S, Rehmel JL, Yi P, Small DS, Zhang W, Suico JG. Cannady EA, et al. Among authors: small ds. Pharmacol Res Perspect. 2015 Oct;3(5):e00179. doi: 10.1002/prp2.179. Epub 2015 Oct 12. Pharmacol Res Perspect. 2015. PMID: 26516590 Free PMC article.

7

Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel.

Payne CD, Li YG, Small DS, Ernest CS 2nd, Farid NA, Jakubowski JA, Brandt JT, Salazar DE, Winters KJ. Payne CD, et al. Among authors: small ds. J Cardiovasc Pharmacol. 2007 Nov;50(5):555-62. doi: 10.1097/FJC.0b013e3181492209. J Cardiovasc Pharmacol. 2007. PMID: 18030066 Clinical Trial.

8

Pharmacokinetic-pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis.

Macias WL, Dhainaut JF, Yan SC, Helterbrand JD, Seger M, Johnson G 3rd, Small DS. Macias WL, et al. Among authors: small ds. Clin Pharmacol Ther. 2002 Oct;72(4):391-402. doi: 10.1067/mcp.2002.128148. Clin Pharmacol Ther. 2002. PMID: 12386641 Clinical Trial.

9

The onset of inhibition of platelet aggregation with prasugrel compared with clopidogrel loading doses using gatekeeping analysis of integrated clinical pharmacology data.

Zhu B, Effron MB, Kulkarni MP, Li YG, Jakubowski JA, Miller DL, Baker BA, Luo J, Small DS, Winters KJ. Zhu B, et al. Among authors: small ds. J Cardiovasc Pharmacol. 2011 Mar;57(3):317-24. doi: 10.1097/FJC.0b013e3182073dfb. J Cardiovasc Pharmacol. 2011. PMID: 21266916

10

Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently.

Farid NA, Payne CD, Small DS, Winters KJ, Ernest CS 2nd, Brandt JT, Darstein C, Jakubowski JA, Salazar DE. Farid NA, et al. Among authors: small ds. Clin Pharmacol Ther. 2007 May;81(5):735-41. doi: 10.1038/sj.clpt.6100139. Epub 2007 Mar 14. Clin Pharmacol Ther. 2007. PMID: 17361128 Clinical Trial.

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