De Clercq E - Search Results

1

Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.

Baba M, Tanaka H, De Clercq E, Pauwels R, Balzarini J, Schols D, Nakashima H, Perno CF, Walker RT, Miyasaka T. Baba M, et al. Among authors: de clercq e. Biochem Biophys Res Commun. 1989 Dec 29;165(3):1375-81. doi: 10.1016/0006-291x(89)92756-3. Biochem Biophys Res Commun. 1989. PMID: 2575380

2

Assay method for monitoring the inhibitory effects of antimetabolites on the activity of inosinate dehydrogenase in intact human CEM lymphocytes.

Balzarini J, De Clercq E. Balzarini J, et al. Among authors: de clercq e. Biochem J. 1992 Nov 1;287 ( Pt 3)(Pt 3):785-90. doi: 10.1042/bj2870785. Biochem J. 1992. PMID: 1359876 Free PMC article.

3

2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase.

Balzarini J, Pérez-Pérez MJ, San-Félix A, Schols D, Perno CF, Vandamme AM, Camarasa MJ, De Clercq E. Balzarini J, et al. Among authors: de clercq e. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4392-6. doi: 10.1073/pnas.89.10.4392. Proc Natl Acad Sci U S A. 1992. PMID: 1374900 Free PMC article.

4

Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase.

Debyser Z, Pauwels R, Baba M, Desmyter J, De Clercq E. Debyser Z, et al. Among authors: de clercq e. Mol Pharmacol. 1992 May;41(5):963-8. Mol Pharmacol. 1992. PMID: 1375320

5

Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives.

Debyser Z, Vandamme AM, Pauwels R, Baba M, Desmyter J, De Clercq E. Debyser Z, et al. Among authors: de clercq e. J Biol Chem. 1992 Jun 15;267(17):11769-76. J Biol Chem. 1992. PMID: 1376311 Free article.

6

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

De Clercq E, Yamamoto N, Pauwels R, Baba M, Schols D, Nakashima H, Balzarini J, Debyser Z, Murrer BA, Schwartz D, et al. De Clercq E, et al. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5286-90. doi: 10.1073/pnas.89.12.5286. Proc Natl Acad Sci U S A. 1992. PMID: 1608936 Free PMC article.

7

Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro.

Balzarini J, Schols D, Neyts J, Van Damme E, Peumans W, De Clercq E. Balzarini J, et al. Among authors: de clercq e. Antimicrob Agents Chemother. 1991 Mar;35(3):410-6. doi: 10.1128/AAC.35.3.410. Antimicrob Agents Chemother. 1991. PMID: 1645507 Free PMC article.

8

1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2',3'-dideoxyinosine on human immunodeficiency virus in peripheral blood lymphocytes.

Balzarini J, Lee CK, Schols D, De Clercq E. Balzarini J, et al. Among authors: de clercq e. Biochem Biophys Res Commun. 1991 Jul 31;178(2):563-9. doi: 10.1016/0006-291x(91)90145-w. Biochem Biophys Res Commun. 1991. PMID: 1650194

9

Sulfated polysaccharides as potent inhibitors of HIV-induced syncytium formation: a new strategy towards AIDS chemotherapy.

Baba M, Schols D, Pauwels R, Nakashima H, De Clercq E. Baba M, et al. Among authors: de clercq e. J Acquir Immune Defic Syndr (1988). 1990;3(5):493-9. J Acquir Immune Defic Syndr (1988). 1990. PMID: 1691288

10

9-Beta-D-arabinofuranosyladenine 5'-monophosphate (araAMP) is converted directly to its antivirally active 5'-triphosphate form by 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase.

Balzarini J, De Clercq E. Balzarini J, et al. Among authors: de clercq e. Biochem Biophys Res Commun. 1990 Dec 31;173(3):781-7. doi: 10.1016/s0006-291x(05)80855-1. Biochem Biophys Res Commun. 1990. PMID: 1702630

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