Ayoub D - Search Results

1

Characterization of the N-terminal heterogeneities of monoclonal antibodies using in-gel charge derivatization of α-amines and LC-MS/MS.

Ayoub D, Bertaccini D, Diemer H, Wagner-Rousset E, Colas O, Cianférani S, Van Dorsselaer A, Beck A, Schaeffer-Reiss C. Ayoub D, et al. Anal Chem. 2015 Apr 7;87(7):3784-90. doi: 10.1021/ac504427k. Epub 2015 Mar 26. Anal Chem. 2015. PMID: 25769014

2

Characterization of therapeutic antibodies and related products.

Beck A, Wagner-Rousset E, Ayoub D, Van Dorsselaer A, Sanglier-Cianférani S. Beck A, et al. Among authors: ayoub d. Anal Chem. 2013 Jan 15;85(2):715-36. doi: 10.1021/ac3032355. Epub 2012 Dec 14. Anal Chem. 2013. PMID: 23134362 Review. No abstract available.

3

Time resolved native ion-mobility mass spectrometry to monitor dynamics of IgG4 Fab arm exchange and "bispecific" monoclonal antibody formation.

Debaene F, Wagner-Rousset E, Colas O, Ayoub D, Corvaïa N, Van Dorsselaer A, Beck A, Cianférani S. Debaene F, et al. Among authors: ayoub d. Anal Chem. 2013 Oct 15;85(20):9785-92. doi: 10.1021/ac402237v. Epub 2013 Sep 26. Anal Chem. 2013. PMID: 24007193

4

Middle-down analysis of monoclonal antibodies with electron transfer dissociation orbitrap fourier transform mass spectrometry.

Fornelli L, Ayoub D, Aizikov K, Beck A, Tsybin YO. Fornelli L, et al. Among authors: ayoub d. Anal Chem. 2014 Mar 18;86(6):3005-12. doi: 10.1021/ac4036857. Epub 2014 Mar 3. Anal Chem. 2014. PMID: 24588056

5

Advantages of extended bottom-up proteomics using Sap9 for analysis of monoclonal antibodies.

Srzentić K, Fornelli L, Laskay ÜA, Monod M, Beck A, Ayoub D, Tsybin YO. Srzentić K, et al. Among authors: ayoub d. Anal Chem. 2014 Oct 7;86(19):9945-53. doi: 10.1021/ac502766n. Epub 2014 Sep 24. Anal Chem. 2014. PMID: 25207962

6

Innovative native MS methodologies for antibody drug conjugate characterization: High resolution native MS and IM-MS for average DAR and DAR distribution assessment.

Debaene F, Boeuf A, Wagner-Rousset E, Colas O, Ayoub D, Corvaïa N, Van Dorsselaer A, Beck A, Cianférani S. Debaene F, et al. Among authors: ayoub d. Anal Chem. 2014 Nov 4;86(21):10674-83. doi: 10.1021/ac502593n. Epub 2014 Oct 21. Anal Chem. 2014. PMID: 25270580

7

Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques.

Ayoub D, Jabs W, Resemann A, Evers W, Evans C, Main L, Baessmann C, Wagner-Rousset E, Suckau D, Beck A. Ayoub D, et al. MAbs. 2013 Sep-Oct;5(5):699-710. doi: 10.4161/mabs.25423. Epub 2013 Jun 20. MAbs. 2013. PMID: 23924801 Free PMC article.

8

N-terminome analysis of the human mitochondrial proteome.

Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C. Vaca Jacome AS, et al. Among authors: ayoub d. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. Proteomics. 2015. PMID: 25944712

9

Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody.

Srzentić K, Nagornov KO, Fornelli L, Lobas AA, Ayoub D, Kozhinov AN, Gasilova N, Menin L, Beck A, Gorshkov MV, Aizikov K, Tsybin YO. Srzentić K, et al. Among authors: ayoub d. Anal Chem. 2018 Nov 6;90(21):12527-12535. doi: 10.1021/acs.analchem.8b02398. Epub 2018 Oct 12. Anal Chem. 2018. PMID: 30252447

10

Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion.

Wagner-Rousset E, Janin-Bussat MC, Colas O, Excoffier M, Ayoub D, Haeuw JF, Rilatt I, Perez M, Corvaïa N, Beck A. Wagner-Rousset E, et al. Among authors: ayoub d. MAbs. 2014 Jan-Feb;6(1):273-85. doi: 10.4161/mabs.26773. MAbs. 2014. PMID: 24135617 Free PMC article.

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