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Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
Hecker SJ, Reddy KR, Totrov M, Hirst GC, Lomovskaya O, Griffith DC, King P, Tsivkovski R, Sun D, Sabet M, Tarazi Z, Clifton MC, Atkins K, Raymond A, Potts KT, Abendroth J, Boyer SH, Loutit JS, Morgan EE, Durso S, Dudley MN. Hecker SJ, et al. Among authors: abendroth j. J Med Chem. 2015 May 14;58(9):3682-92. doi: 10.1021/acs.jmedchem.5b00127. Epub 2015 Mar 17. J Med Chem. 2015. PMID: 25782055
Characterization of an Acinetobacter baumannii Monofunctional Phosphomethylpyrimidine Kinase That Is Inhibited by Pyridoxal Phosphate.
De Vitto H, Belfon KKJ, Sharma N, Toay S, Abendroth J, Dranow DM, Lukacs CM, Choi R, Udell HS, Willis S, Barrera G, Beyer O, Li TD, Hicks KA, Torelli AT, French JB. De Vitto H, et al. Among authors: abendroth j. Biochemistry. 2024 Feb 2:10.1021/acs.biochem.3c00640. doi: 10.1021/acs.biochem.3c00640. Online ahead of print. Biochemistry. 2024. PMID: 38306231
Structures of Brucella ovis leucine-, isoleucine-, valine-, threonine- and alanine-binding protein reveal a conformationally flexible peptide-binding cavity.
Chakafana G, Boswell R, Chandler A, Jackson KA, Neblett S, Postal T, Subramanian S, Abendroth J, Myler PJ, Asojo OA. Chakafana G, et al. Among authors: abendroth j. Acta Crystallogr F Struct Biol Commun. 2024 Sep 1;80(Pt 9):193-199. doi: 10.1107/S2053230X24007027. Epub 2024 Aug 23. Acta Crystallogr F Struct Biol Commun. 2024. PMID: 39177244 Free PMC article.
In Vitro and In Vivo Efficacy of NITD-916 against Mycobacterium fortuitum.
Roquet-Banères F, Alcaraz M, Hamela C, Abendroth J, Edwards TE, Kremer L. Roquet-Banères F, et al. Among authors: abendroth j. Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0160722. doi: 10.1128/aac.01607-22. Epub 2023 Mar 15. Antimicrob Agents Chemother. 2023. PMID: 36920188 Free PMC article.
Characterization of a family I inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1.
Moorefield J, Konuk Y, Norman JO, Abendroth J, Edwards TE, Lorimer DD, Mayclin SJ, Staker BL, Craig JK, Barett KF, Barrett LK, Van Voorhis WC, Myler PJ, McLaughlin KJ. Moorefield J, et al. Among authors: abendroth j. Acta Crystallogr F Struct Biol Commun. 2023 Oct 1;79(Pt 10):257-266. doi: 10.1107/S2053230X23008002. Epub 2023 Sep 20. Acta Crystallogr F Struct Biol Commun. 2023. PMID: 37728609 Free PMC article.
Structure of the Reston ebolavirus VP30 C-terminal domain.
Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO. Clifton MC, et al. Among authors: abendroth j. Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):457-60. doi: 10.1107/S2053230X14003811. Epub 2014 Mar 25. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 24699737 Free PMC article.
Increasing the structural coverage of tuberculosis drug targets.
Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ. Baugh L, et al. Among authors: abendroth j. Tuberculosis (Edinb). 2015 Mar;95(2):142-8. doi: 10.1016/j.tube.2014.12.003. Epub 2014 Dec 19. Tuberculosis (Edinb). 2015. PMID: 25613812 Free PMC article.
140 results