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Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.
Ma C, Wang N, Detre C, Wang G, O'Keeffe M, Terhorst C. Ma C, et al. Among authors: wang g, wang n. J Biol Chem. 2012 May 25;287(22):18359-65. doi: 10.1074/jbc.M112.367060. Epub 2012 Apr 9. J Biol Chem. 2012. PMID: 22493499 Free PMC article.
Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages.
Wang G, Abadía-Molina AC, Berger SB, Romero X, O'Keeffe MS, Rojas-Barros DI, Aleman M, Liao G, Maganto-García E, Fresno M, Wang N, Detre C, Terhorst C. Wang G, et al. Among authors: wang n. J Immunol. 2012 Jun 15;188(12):5829-32. doi: 10.4049/jimmunol.1102620. Epub 2012 May 16. J Immunol. 2012. PMID: 22593622 Free PMC article.
Signaling lymphocyte activation molecule regulates development of colitis in mice.
van Driel B, Liao G, Romero X, O'Keeffe MS, Wang G, Faubion WA, Berger SB, Magelky EM, Manocha M, Azcutia V, Grisham M, Luscinskas FW, Mizoguchi E, de Waal Malefyt R, Reinecker HC, Bhan AK, Wang N, Terhorst C. van Driel B, et al. Among authors: wang g, wang n. Gastroenterology. 2012 Dec;143(6):1544-1554.e7. doi: 10.1053/j.gastro.2012.08.042. Epub 2012 Sep 6. Gastroenterology. 2012. PMID: 22960654 Free PMC article.
SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages.
Berger SB, Romero X, Ma C, Wang G, Faubion WA, Liao G, Compeer E, Keszei M, Rameh L, Wang N, Boes M, Regueiro JR, Reinecker HC, Terhorst C. Berger SB, et al. Among authors: wang g, wang n. Nat Immunol. 2010 Oct;11(10):920-7. doi: 10.1038/ni.1931. Epub 2010 Sep 5. Nat Immunol. 2010. PMID: 20818396 Free PMC article.
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