Hentze H - Search Results

1

Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.

Chu X, Shih SJ, Shaw R, Hentze H, Chan GH, Owens K, Wang S, Cai X, Newton D, Castro-Perez J, Salituro G, Palamanda J, Fernandis A, Ng CK, Liaw A, Savage MJ, Evers R. Chu X, et al. Among authors: hentze h. Drug Metab Dispos. 2015 Jun;43(6):851-63. doi: 10.1124/dmd.115.063347. Epub 2015 Mar 26. Drug Metab Dispos. 2015. PMID: 25813937

2

Inverse relationship between LDL cholesterol and PCSK9 plasma levels in dyslipidemic cynomolgus monkeys: effects of LDL lowering by ezetimibe in the absence of statins.

Hentze H, Jensen KK, Chia SM, Johns DG, Shaw RJ, Davis HR Jr, Shih SJ, Wong KK. Hentze H, et al. Atherosclerosis. 2013 Nov;231(1):84-90. doi: 10.1016/j.atherosclerosis.2013.08.028. Epub 2013 Sep 5. Atherosclerosis. 2013. PMID: 24125416

3

Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin.

Hentze H, Lin XY, Choi MS, Porter AG. Hentze H, et al. Cell Death Differ. 2003 Sep;10(9):956-68. doi: 10.1038/sj.cdd.4401264. Cell Death Differ. 2003. PMID: 12934070

4

SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer.

Novotny-Diermayr V, Sangthongpitag K, Hu CY, Wu X, Sausgruber N, Yeo P, Greicius G, Pettersson S, Liang AL, Loh YK, Bonday Z, Goh KC, Hentze H, Hart S, Wang H, Ethirajulu K, Wood JM. Novotny-Diermayr V, et al. Among authors: hentze h. Mol Cancer Ther. 2010 Mar;9(3):642-52. doi: 10.1158/1535-7163.MCT-09-0689. Epub 2010 Mar 2. Mol Cancer Ther. 2010. PMID: 20197387

5

Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI.

Rajendran R, Huang W, Tang AM, Liang JM, Choo S, Reese T, Hentze H, van Boxtel S, Cliffe A, Rogers K, Henry B, Chuang KH. Rajendran R, et al. Among authors: hentze h. Cancer Med. 2014 Feb;3(1):47-60. doi: 10.1002/cam4.177. Epub 2014 Jan 6. Cancer Med. 2014. PMID: 24403176 Free PMC article.

6

Teratoma formation by human embryonic stem cells: evaluation of essential parameters for future safety studies.

Hentze H, Soong PL, Wang ST, Phillips BW, Putti TC, Dunn NR. Hentze H, et al. Stem Cell Res. 2009 May;2(3):198-210. doi: 10.1016/j.scr.2009.02.002. Epub 2009 Feb 12. Stem Cell Res. 2009. PMID: 19393593 Free article.

7

Pharmacodynamic evaluation of the target efficacy of SB939, an oral HDAC inhibitor with selectivity for tumor tissue.

Novotny-Diermayr V, Sausgruber N, Loh YK, Pasha MK, Jayaraman R, Hentze H, Yong WP, Goh BC, Toh HC, Ethirajulu K, Zhu J, Wood JM. Novotny-Diermayr V, et al. Among authors: hentze h. Mol Cancer Ther. 2011 Jul;10(7):1207-17. doi: 10.1158/1535-7163.MCT-11-0044. Epub 2011 May 17. Mol Cancer Ther. 2011. PMID: 21586629 Free article.

8

SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies.

Hart S, Goh KC, Novotny-Diermayr V, Hu CY, Hentze H, Tan YC, Madan B, Amalini C, Loh YK, Ong LC, William AD, Lee A, Poulsen A, Jayaraman R, Ong KH, Ethirajulu K, Dymock BW, Wood JW. Hart S, et al. Among authors: hentze h. Leukemia. 2011 Nov;25(11):1751-9. doi: 10.1038/leu.2011.148. Epub 2011 Jun 21. Leukemia. 2011. PMID: 21691275

9

The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML.

Novotny-Diermayr V, Hart S, Goh KC, Cheong A, Ong LC, Hentze H, Pasha MK, Jayaraman R, Ethirajulu K, Wood JM. Novotny-Diermayr V, et al. Among authors: hentze h. Blood Cancer J. 2012 May;2(5):e69. doi: 10.1038/bcj.2012.14. Epub 2012 May 4. Blood Cancer J. 2012. PMID: 22829971 Free PMC article.

10

Topoisomerase inhibitor camptothecin sensitizes mouse hepatocytes in vitro and in vivo to TNF-mediated apoptosis.

Hentze H, Latta M, Künstle G, Dhakshinamoorthy S, Ng PY, Porter AG, Wendel A. Hentze H, et al. Hepatology. 2004 May;39(5):1311-20. doi: 10.1002/hep.20174. Hepatology. 2004. PMID: 15122760

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