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Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.
Chu X, Shih SJ, Shaw R, Hentze H, Chan GH, Owens K, Wang S, Cai X, Newton D, Castro-Perez J, Salituro G, Palamanda J, Fernandis A, Ng CK, Liaw A, Savage MJ, Evers R. Chu X, et al. Among authors: wang s. Drug Metab Dispos. 2015 Jun;43(6):851-63. doi: 10.1124/dmd.115.063347. Epub 2015 Mar 26. Drug Metab Dispos. 2015. PMID: 25813937
Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey.
Jensen KK, Tadin-Strapps M, Wang SP, Hubert J, Kan Y, Ma Y, McLaren DG, Previs SF, Herath KB, Mahsut A, Liaw A, Wang S, Stout SJ, Keohan C, Forrest G, Coelho D, Yendluri S, Williams S, Koser M, Bartz S, Akinsanya KO, Pinto S. Jensen KK, et al. Among authors: wang sp, wang s. J Lipid Res. 2016 Dec;57(12):2150-2162. doi: 10.1194/jlr.M071498. Epub 2016 Oct 5. J Lipid Res. 2016. PMID: 27707816 Free PMC article.
Effects of carvedilol on structural and functional outcomes and plasma biomarkers in the mouse transverse aortic constriction heart failure model.
Hampton C, Rosa R, Szeto D, Forrest G, Campbell B, Kennan R, Wang S, Huang CH, Gichuru L, Ping X, Shen X, Small K, Madwed J, Lynch JJ. Hampton C, et al. Among authors: wang s. SAGE Open Med. 2017 Mar 30;5:2050312117700057. doi: 10.1177/2050312117700057. eCollection 2017. SAGE Open Med. 2017. PMID: 28491305 Free PMC article.
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