Xu S - Search Results

1

Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2.

Blobaum AL, Xu S, Rowlinson SW, Duggan KC, Banerjee S, Kudalkar SN, Birmingham WR, Ghebreselasie K, Marnett LJ. Blobaum AL, et al. Among authors: xu s. J Biol Chem. 2015 May 15;290(20):12793-803. doi: 10.1074/jbc.M114.635987. Epub 2015 Mar 30. J Biol Chem. 2015. PMID: 25825493 Free PMC article.

2

Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxib.

Windsor MA, Valk PL, Xu S, Banerjee S, Marnett LJ. Windsor MA, et al. Among authors: xu s. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5860-4. doi: 10.1016/j.bmcl.2013.08.097. Epub 2013 Sep 6. Bioorg Med Chem Lett. 2013. PMID: 24060487 Free PMC article.

3

Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network.

Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ. Xu S, et al. J Biol Chem. 2014 Mar 7;289(10):6799-6808. doi: 10.1074/jbc.M113.517987. Epub 2014 Jan 14. J Biol Chem. 2014. PMID: 24425867 Free PMC article.

4

13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase.

Kudalkar SN, Nikas SP, Kingsley PJ, Xu S, Galligan JJ, Rouzer CA, Banerjee S, Ji L, Eno MR, Makriyannis A, Marnett LJ. Kudalkar SN, et al. Among authors: xu s. J Biol Chem. 2015 Mar 20;290(12):7897-909. doi: 10.1074/jbc.M114.634014. Epub 2015 Feb 2. J Biol Chem. 2015. PMID: 25648895 Free PMC article.

5

Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors.

Uddin MJ, Crews BC, Xu S, Ghebreselasie K, Daniel CK, Kingsley PJ, Banerjee S, Marnett LJ. Uddin MJ, et al. Among authors: xu s. ACS Chem Biol. 2016 Nov 18;11(11):3052-3060. doi: 10.1021/acschembio.6b00560. Epub 2016 Sep 19. ACS Chem Biol. 2016. PMID: 27588346 Free PMC article.

6

Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.

Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ. Goodman MC, et al. Among authors: xu s. J Biol Chem. 2018 Mar 2;293(9):3028-3038. doi: 10.1074/jbc.M117.802058. Epub 2018 Jan 11. J Biol Chem. 2018. PMID: 29326169 Free PMC article.

7

Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site.

Xu S, Uddin MJ, Banerjee S, Duggan K, Musee J, Kiefer JR, Ghebreselasie K, Rouzer CA, Marnett LJ. Xu S, et al. J Biol Chem. 2019 May 31;294(22):8690-8698. doi: 10.1074/jbc.RA119.007405. Epub 2019 Apr 18. J Biol Chem. 2019. PMID: 31000626 Free PMC article.

8

Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes.

Windsor MA, Hermanson DJ, Kingsley PJ, Xu S, Crews BC, Ho W, Keenan CM, Banerjee S, Sharkey KA, Marnett LJ. Windsor MA, et al. Among authors: xu s. ACS Med Chem Lett. 2012 Sep 13;3(9):759-763. doi: 10.1021/ml3001616. Epub 2012 Aug 15. ACS Med Chem Lett. 2012. PMID: 22984634 Free PMC article.

9

Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond.

Xu S, Rouzer CA, Marnett LJ. Xu S, et al. IUBMB Life. 2014 Dec;66(12):803-11. doi: 10.1002/iub.1334. Epub 2014 Dec 23. IUBMB Life. 2014. PMID: 25537198 Free PMC article. Review.

10

nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2.

Neumann W, Xu S, Sárosi MB, Scholz MS, Crews BC, Ghebreselasie K, Banerjee S, Marnett LJ, Hey-Hawkins E. Neumann W, et al. Among authors: xu s. ChemMedChem. 2016 Jan 19;11(2):175-8. doi: 10.1002/cmdc.201500199. Epub 2015 Jun 18. ChemMedChem. 2016. PMID: 26088701 Free PMC article.

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