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886 results

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Page 1
Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors.
Haffner CD, Becherer JD, Boros EE, Cadilla R, Carpenter T, Cowan D, Deaton DN, Guo Y, Harrington W, Henke BR, Jeune MR, Kaldor I, Milliken N, Petrov KG, Preugschat F, Schulte C, Shearer BG, Shearer T, Smalley TL Jr, Stewart EL, Stuart JD, Ulrich JC. Haffner CD, et al. Among authors: carpenter t. J Med Chem. 2015 Apr 23;58(8):3548-71. doi: 10.1021/jm502009h. Epub 2015 Apr 10. J Med Chem. 2015. PMID: 25828863
Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38.
Becherer JD, Boros EE, Carpenter TY, Cowan DJ, Deaton DN, Haffner CD, Jeune MR, Kaldor IW, Poole JC, Preugschat F, Rheault TR, Schulte CA, Shearer BG, Shearer TW, Shewchuk LM, Smalley TL Jr, Stewart EL, Stuart JD, Ulrich JC. Becherer JD, et al. J Med Chem. 2015 Sep 10;58(17):7021-56. doi: 10.1021/acs.jmedchem.5b00992. Epub 2015 Aug 24. J Med Chem. 2015. PMID: 26267483
Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility.
Chiang SH, Harrington WW, Luo G, Milliken NO, Ulrich JC, Chen J, Rajpal DK, Qian Y, Carpenter T, Murray R, Geske RS, Stimpson SA, Kramer HF, Haffner CD, Becherer JD, Preugschat F, Billin AN. Chiang SH, et al. Among authors: carpenter t. PLoS One. 2015 Aug 19;10(8):e0134927. doi: 10.1371/journal.pone.0134927. eCollection 2015. PLoS One. 2015. PMID: 26287487 Free PMC article.
Substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 ion channel blockers. Part 2.
Haffner CD, Thomson SA, Guo Y, Petrov K, Larkin A, Banker P, Schaaf G, Dickerson S, Gobel J, Gillie D, Condreay JP, Poole C, Carpenter T, Ulrich J. Haffner CD, et al. Among authors: carpenter t. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6989-92. doi: 10.1016/j.bmcl.2010.09.131. Epub 2010 Oct 23. Bioorg Med Chem Lett. 2010. PMID: 20974533
Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).
Deng H, O'Keefe H, Davie CP, Lind KE, Acharya RA, Franklin GJ, Larkin J, Matico R, Neeb M, Thompson MM, Lohr T, Gross JW, Centrella PA, O'Donovan GK, Bedard KL, van Vloten K, Mataruse S, Skinner SR, Belyanskaya SL, Carpenter TY, Shearer TW, Clark MA, Cuozzo JW, Arico-Muendel CC, Morgan BA. Deng H, et al. Among authors: carpenter ty. J Med Chem. 2012 Aug 23;55(16):7061-79. doi: 10.1021/jm300449x. Epub 2012 Aug 14. J Med Chem. 2012. PMID: 22891645
Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies.
Faustino EVS, Kandil SB, Leroue MK, Sochet AA, Kong M, Cholette JM, Nellis ME, Pinto MG, Chegondi M, Ramirez M, Schreiber H, Kerris EWJ, Glau CL, Kolmar A, Muisyo TM, Sharathkumar A, Polikoff L, Silva CT, Ehrlich L, Navarro OM, Spinella PC, Raffini L, Taylor SN, McPartland T, Shabanova V; Catheter-Related Early Thromboprophylaxis with Enoxaparin (CRETE) Studies Investigators and the Pediatric Critical Care Blood Research Network (BloodNet) of the Pediatric Acute Lung Injury and Sepsis Investigators Network (PALISI). Faustino EVS, et al. Pediatr Crit Care Med. 2024 Nov 19. doi: 10.1097/PCC.0000000000003648. Online ahead of print. Pediatr Crit Care Med. 2024. PMID: 39560771
Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections.
Lydon E, Osborne CM, Wagner BD, Ambroggio L, Kirk Harris J, Reeder R, Carpenter TC, Maddux AB, Leroue MK, Yehya N, DeRisi JL, Hall MW, Zuppa AF, Carcillo J, Meert K, Sapru A, Pollack MM, McQuillen P, Notterman DA, Langelier CR, Mourani PM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN). Lydon E, et al. Among authors: carpenter tc. bioRxiv [Preprint]. 2024 Oct 10:2024.10.08.617294. doi: 10.1101/2024.10.08.617294. bioRxiv. 2024. PMID: 39416167 Free PMC article. Preprint.
Generating Protein Structures for Pathway Discovery Using Deep Learning.
Georgouli K, Stephany RR, Tempkin JOB, Santiago C, Aydin F, Heimann MA, Pottier L, Zhang X, Carpenter TS, Hsu T, Nissley DV, Streitz FH, Lightstone FC, Ingolfsson HI, Bremer PT. Georgouli K, et al. Among authors: carpenter ts. J Chem Theory Comput. 2024 Oct 22;20(20):8795-8806. doi: 10.1021/acs.jctc.4c00816. Epub 2024 Oct 10. J Chem Theory Comput. 2024. PMID: 39388723 Free PMC article.
Resuscitation arterial waveform quantification and outcomes in pediatric bidirectional Glenn and Fontan patients.
Yates AR, Hehir DA, Reeder RW, Berger JT, Fernandez R, Frazier AH, Graham K, McQuillen PS, Morgan RW, Nadkarni VM, Naim MY, Palmer CA, Wolfe HA, Berg RA, Sutton RM; ICU-RESUS; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network Investigator Groups. Yates AR, et al. Pediatr Res. 2024 Sep 16. doi: 10.1038/s41390-024-03564-y. Online ahead of print. Pediatr Res. 2024. PMID: 39284966
886 results