Jorda R - Search Results

1

Novel arylazopyrazole inhibitors of cyclin-dependent kinases.

Jorda R, Schütznerová E, Cankař P, Brychtová V, Navrátilová J, Kryštof V. Jorda R, et al. Bioorg Med Chem. 2015 May 1;23(9):1975-81. doi: 10.1016/j.bmc.2015.03.025. Epub 2015 Mar 14. Bioorg Med Chem. 2015. PMID: 25835357

2

Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine.

Paprskárová M, Krystof V, Jorda R, Dzubák P, Hajdúch M, Wesierska-Gadek J, Strnad M. Paprskárová M, et al. Among authors: jorda r. J Cell Biochem. 2009 Jun 1;107(3):428-37. doi: 10.1002/jcb.22139. J Cell Biochem. 2009. PMID: 19308936

3

Pharmacological targeting of CDK9 in cardiac hypertrophy.

Krystof V, Chamrád I, Jorda R, Kohoutek J. Krystof V, et al. Among authors: jorda r. Med Res Rev. 2010 Jul;30(4):646-66. doi: 10.1002/med.20172. Med Res Rev. 2010. PMID: 19757441 Review.

4

Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity.

Jorda R, Havlícek L, McNae IW, Walkinshaw MD, Voller J, Sturc A, Navrátilová J, Kuzma M, Mistrík M, Bártek J, Strnad M, Krystof V. Jorda R, et al. J Med Chem. 2011 Apr 28;54(8):2980-93. doi: 10.1021/jm200064p. Epub 2011 Apr 6. J Med Chem. 2011. PMID: 21417417

5

Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3-d]pyrimidines.

Jorda R, Sacerdoti-Sierra N, Voller J, Havlíček L, Kráčalíková K, Nowicki MW, Nasereddin A, Kryštof V, Strnad M, Walkinshaw MD, Jaffe CL. Jorda R, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4233-7. doi: 10.1016/j.bmcl.2011.05.076. Epub 2011 May 27. Bioorg Med Chem Lett. 2011. PMID: 21683592

6

The selective P-TEFb inhibitor CAN508 targets angiogenesis.

Kryštof V, Rárová L, Liebl J, Zahler S, Jorda R, Voller J, Cankař P. Kryštof V, et al. Among authors: jorda r. Eur J Med Chem. 2011 Sep;46(9):4289-94. doi: 10.1016/j.ejmech.2011.06.035. Epub 2011 Jul 3. Eur J Med Chem. 2011. PMID: 21777997

7

Cyclin-dependent kinase inhibitors inspired by roscovitine: purine bioisosteres.

Jorda R, Paruch K, Krystof V. Jorda R, et al. Curr Pharm Des. 2012;18(20):2974-80. doi: 10.2174/138161212800672804. Curr Pharm Des. 2012. PMID: 22571665 Review.

8

Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases.

Zatloukal M, Jorda R, Gucký T, Řezníčková E, Voller J, Pospíšil T, Malínková V, Adamcová H, Kryštof V, Strnad M. Zatloukal M, et al. Among authors: jorda r. Eur J Med Chem. 2013 Mar;61:61-72. doi: 10.1016/j.ejmech.2012.06.036. Epub 2012 Jun 23. Eur J Med Chem. 2013. PMID: 22770608

9

A novel series of highly potent 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitors.

Gucký T, Jorda R, Zatloukal M, Bazgier V, Berka K, Řezníčková E, Béres T, Strnad M, Kryštof V. Gucký T, et al. Among authors: jorda r. J Med Chem. 2013 Aug 8;56(15):6234-47. doi: 10.1021/jm4006884. Epub 2013 Jul 24. J Med Chem. 2013. PMID: 23829517

10

Novel inhibitors of cyclin-dependent kinases combat hepatocellular carcinoma without inducing chemoresistance.

Haider C, Grubinger M, Řezníčková E, Weiss TS, Rotheneder H, Miklos W, Berger W, Jorda R, Zatloukal M, Gucky T, Strnad M, Kryštof V, Mikulits W. Haider C, et al. Among authors: jorda r. Mol Cancer Ther. 2013 Oct;12(10):1947-57. doi: 10.1158/1535-7163.MCT-13-0263. Epub 2013 Aug 12. Mol Cancer Ther. 2013. PMID: 23939380

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