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Page 1
Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.
Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S, Cairns RA, Cescon DW, Elford AR, Ye J, Lang PA, Li WY, Wakeham A, Duncan GS, Haight J, You-Ten A, Snow B, Yamamoto K, Ohashi PS, Mak TW. Itsumi M, et al. Among authors: cairns ra. Cell Death Differ. 2015 Nov;22(11):1837-45. doi: 10.1038/cdd.2015.38. Epub 2015 Apr 17. Cell Death Differ. 2015. PMID: 25882048 Free PMC article.
Regulation of cancer cell metabolism.
Cairns RA, Harris IS, Mak TW. Cairns RA, et al. Nat Rev Cancer. 2011 Feb;11(2):85-95. doi: 10.1038/nrc2981. Nat Rev Cancer. 2011. PMID: 21258394 Review.
Cancer cell metabolism.
Cairns RA, Harris I, McCracken S, Mak TW. Cairns RA, et al. Cold Spring Harb Symp Quant Biol. 2011;76:299-311. doi: 10.1101/sqb.2011.76.012856. Epub 2011 Dec 12. Cold Spring Harb Symp Quant Biol. 2011. PMID: 22156302 Review.
IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma.
Cairns RA, Iqbal J, Lemonnier F, Kucuk C, de Leval L, Jais JP, Parrens M, Martin A, Xerri L, Brousset P, Chan LC, Chan WC, Gaulard P, Mak TW. Cairns RA, et al. Blood. 2012 Feb 23;119(8):1901-3. doi: 10.1182/blood-2011-11-391748. Epub 2012 Jan 3. Blood. 2012. PMID: 22215888 Free PMC article.
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.
Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW. Sasaki M, et al. Among authors: cairns ra. Genes Dev. 2012 Sep 15;26(18):2038-49. doi: 10.1101/gad.198200.112. Epub 2012 Aug 27. Genes Dev. 2012. PMID: 22925884 Free PMC article.
Mutant IDH is sufficient to initiate enchondromatosis in mice.
Hirata M, Sasaki M, Cairns RA, Inoue S, Puviindran V, Li WY, Snow BE, Jones LD, Wei Q, Sato S, Tang YJ, Nadesan P, Rockel J, Whetstone H, Poon R, Weng A, Gross S, Straley K, Gliser C, Xu Y, Wunder J, Mak TW, Alman BA. Hirata M, et al. Among authors: cairns ra. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2829-34. doi: 10.1073/pnas.1424400112. Epub 2015 Feb 17. Proc Natl Acad Sci U S A. 2015. PMID: 25730874 Free PMC article.
ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.
Jin S, Chen J, Chen L, Histen G, Lin Z, Gross S, Hixon J, Chen Y, Kung C, Chen Y, Fu Y, Lu Y, Lin H, Cai X, Yang H, Cairns RA, Dorsch M, Su SM, Biller S, Mak TW, Cang Y. Jin S, et al. Among authors: cairns ra. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9088-93. doi: 10.1073/pnas.1510757112. Epub 2015 Jul 6. Proc Natl Acad Sci U S A. 2015. PMID: 26150517 Free PMC article.
Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice.
Hao Z, Cairns RA, Inoue S, Li WY, Sheng Y, Lemonnier F, Wakeham A, Snow BE, Dominguez-Brauer C, Ye J, Larsen DM, Straley KS, Tobin ER, Narayanaswamy R, Gaulard P, Mak TW. Hao Z, et al. Among authors: cairns ra. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1387-92. doi: 10.1073/pnas.1525354113. Epub 2016 Jan 19. Proc Natl Acad Sci U S A. 2016. PMID: 26787889 Free PMC article.
67 results