Tonge PJ - Search Results

1

Translating slow-binding inhibition kinetics into cellular and in vivo effects.

Walkup GK, You Z, Ross PL, Allen EK, Daryaee F, Hale MR, O'Donnell J, Ehmann DE, Schuck VJ, Buurman ET, Choy AL, Hajec L, Murphy-Benenato K, Marone V, Patey SA, Grosser LA, Johnstone M, Walker SG, Tonge PJ, Fisher SL. Walkup GK, et al. Among authors: tonge pj. Nat Chem Biol. 2015 Jun;11(6):416-23. doi: 10.1038/nchembio.1796. Epub 2015 Apr 20. Nat Chem Biol. 2015. PMID: 25894085 Free PMC article.

2

High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.

Sullivan TJ, Truglio JJ, Boyne ME, Novichenok P, Zhang X, Stratton CF, Li HJ, Kaur T, Amin A, Johnson F, Slayden RA, Kisker C, Tonge PJ. Sullivan TJ, et al. Among authors: tonge pj. ACS Chem Biol. 2006 Feb 17;1(1):43-53. doi: 10.1021/cb0500042. ACS Chem Biol. 2006. PMID: 17163639

3

Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway.

Lu H, Tonge PJ. Lu H, et al. Among authors: tonge pj. Acc Chem Res. 2008 Jan;41(1):11-20. doi: 10.1021/ar700156e. Acc Chem Res. 2008. PMID: 18193820 Review.

4

Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.

Xu H, Sullivan TJ, Sekiguchi J, Kirikae T, Ojima I, Stratton CF, Mao W, Rock FL, Alley MR, Johnson F, Walker SG, Tonge PJ. Xu H, et al. Among authors: tonge pj. Biochemistry. 2008 Apr 8;47(14):4228-36. doi: 10.1021/bi800023a. Epub 2008 Mar 13. Biochemistry. 2008. PMID: 18335995 Free PMC article.

5

Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity.

Lu H, England K, am Ende C, Truglio JJ, Luckner S, Reddy BG, Marlenee NL, Knudson SE, Knudson DL, Bowen RA, Kisker C, Slayden RA, Tonge PJ. Lu H, et al. Among authors: tonge pj. ACS Chem Biol. 2009 Mar 20;4(3):221-31. doi: 10.1021/cb800306y. ACS Chem Biol. 2009. PMID: 19206187 Free PMC article.

6

Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin.

Machutta CA, Bommineni GR, Luckner SR, Kapilashrami K, Ruzsicska B, Simmerling C, Kisker C, Tonge PJ. Machutta CA, et al. Among authors: tonge pj. J Biol Chem. 2010 Feb 26;285(9):6161-9. doi: 10.1074/jbc.M109.077909. Epub 2009 Dec 16. J Biol Chem. 2010. PMID: 20018879 Free PMC article.

7

A structural and energetic model for the slow-onset inhibition of the Mycobacterium tuberculosis enoyl-ACP reductase InhA.

Li HJ, Lai CT, Pan P, Yu W, Liu N, Bommineni GR, Garcia-Diaz M, Simmerling C, Tonge PJ. Li HJ, et al. Among authors: tonge pj. ACS Chem Biol. 2014 Apr 18;9(4):986-93. doi: 10.1021/cb400896g. Epub 2014 Mar 10. ACS Chem Biol. 2014. PMID: 24527857 Free PMC article.

8

Time-dependent diaryl ether inhibitors of InhA: structure-activity relationship studies of enzyme inhibition, antibacterial activity, and in vivo efficacy.

Pan P, Knudson SE, Bommineni GR, Li HJ, Lai CT, Liu N, Garcia-Diaz M, Simmerling C, Patil SS, Slayden RA, Tonge PJ. Pan P, et al. Among authors: tonge pj. ChemMedChem. 2014 Apr;9(4):776-91. doi: 10.1002/cmdc.201300429. Epub 2014 Mar 11. ChemMedChem. 2014. PMID: 24616444 Free PMC article.

9

Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor.

Schiebel J, Chang A, Shah S, Lu Y, Liu L, Pan P, Hirschbeck MW, Tareilus M, Eltschkner S, Yu W, Cummings JE, Knudson SE, Bommineni GR, Walker SG, Slayden RA, Sotriffer CA, Tonge PJ, Kisker C. Schiebel J, et al. Among authors: tonge pj. J Biol Chem. 2014 Jun 6;289(23):15987-6005. doi: 10.1074/jbc.M113.532804. Epub 2014 Apr 16. J Biol Chem. 2014. PMID: 24739388 Free PMC article.

10

Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.

Neckles C, Pschibul A, Lai CT, Hirschbeck M, Kuper J, Davoodi S, Zou J, Liu N, Pan P, Shah S, Daryaee F, Bommineni GR, Lai C, Simmerling C, Kisker C, Tonge PJ. Neckles C, et al. Among authors: tonge pj. Biochemistry. 2016 May 31;55(21):2992-3006. doi: 10.1021/acs.biochem.5b01301. Epub 2016 May 17. Biochemistry. 2016. PMID: 27136302 Free PMC article.

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