Marchiq I - Search Results

1

Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status.

Granja S, Marchiq I, Le Floch R, Moura CS, Baltazar F, Pouysségur J. Granja S, et al. Among authors: marchiq i. Oncotarget. 2015 Mar 30;6(9):6708-21. doi: 10.18632/oncotarget.2862. Oncotarget. 2015. PMID: 25894929 Free PMC article.

2

Gene disruption using zinc finger nuclease technology.

Granja S, Marchiq I, Baltazar F, Pouysségur J. Granja S, et al. Among authors: marchiq i. Methods Mol Biol. 2014;1165:253-60. doi: 10.1007/978-1-4939-0856-1_17. Methods Mol Biol. 2014. PMID: 24839030

3

Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin.

Marchiq I, Le Floch R, Roux D, Simon MP, Pouyssegur J. Marchiq I, et al. Cancer Res. 2015 Jan 1;75(1):171-80. doi: 10.1158/0008-5472.CAN-14-2260. Epub 2014 Nov 17. Cancer Res. 2015. PMID: 25403912

4

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters.

Marchiq I, Pouysségur J. Marchiq I, et al. J Mol Med (Berl). 2016 Feb;94(2):155-71. doi: 10.1007/s00109-015-1307-x. Epub 2015 Jun 24. J Mol Med (Berl). 2016. PMID: 26099350 Free PMC article. Review.

5

Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction.

Marchiq I, Albrengues J, Granja S, Gaggioli C, Pouysségur J, Simon MP. Marchiq I, et al. Oncotarget. 2015 Sep 22;6(28):24636-48. doi: 10.18632/oncotarget.4323. Oncotarget. 2015. PMID: 26284589 Free PMC article.

6

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.

Le Floch R, Chiche J, Marchiq I, Naiken T, Ilc K, Murray CM, Critchlow SE, Roux D, Simon MP, Pouysségur J. Le Floch R, et al. Among authors: marchiq i. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16663-8. doi: 10.1073/pnas.1106123108. Epub 2011 Sep 19. Proc Natl Acad Sci U S A. 2011. PMID: 21930917 Free PMC article.

7

Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export.

Parks SK, Cormerais Y, Marchiq I, Pouyssegur J. Parks SK, et al. Among authors: marchiq i. Mol Aspects Med. 2016 Feb-Mar;47-48:3-14. doi: 10.1016/j.mam.2015.12.001. Epub 2015 Dec 23. Mol Aspects Med. 2016. PMID: 26724171 Review.

8

Na(+)/H(+) antiporter (NHE1) and lactate/H(+) symporters (MCTs) in pH homeostasis and cancer metabolism.

Counillon L, Bouret Y, Marchiq I, Pouysségur J. Counillon L, et al. Among authors: marchiq i. Biochim Biophys Acta. 2016 Oct;1863(10):2465-80. doi: 10.1016/j.bbamcr.2016.02.018. Epub 2016 Mar 2. Biochim Biophys Acta. 2016. PMID: 26944480 Free article. Review.

9

Disrupting the 'Warburg effect' re-routes cancer cells to OXPHOS offering a vulnerability point via 'ferroptosis'-induced cell death.

Ždralević M, Vučetić M, Daher B, Marchiq I, Parks SK, Pouysségur J. Ždralević M, et al. Among authors: marchiq i. Adv Biol Regul. 2018 May;68:55-63. doi: 10.1016/j.jbior.2017.12.002. Epub 2017 Dec 28. Adv Biol Regul. 2018. PMID: 29306548 Free article. Review.

10

Metabolic Plasiticy in Cancers-Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs.

Ždralević M, Marchiq I, de Padua MMC, Parks SK, Pouysségur J. Ždralević M, et al. Among authors: marchiq i. Front Oncol. 2017 Dec 20;7:313. doi: 10.3389/fonc.2017.00313. eCollection 2017. Front Oncol. 2017. PMID: 29326883 Free PMC article. Review.

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