Wittinghofer A - Search Results

1

Structural Characterization of LRRK2 Inhibitors.

Gilsbach BK, Messias AC, Ito G, Sattler M, Alessi DR, Wittinghofer A, Kortholt A. Gilsbach BK, et al. Among authors: wittinghofer a. J Med Chem. 2015 May 14;58(9):3751-6. doi: 10.1021/jm5018779. Epub 2015 May 1. J Med Chem. 2015. PMID: 25897865

2

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.

Gilsbach BK, Ho FY, Vetter IR, van Haastert PJ, Wittinghofer A, Kortholt A. Gilsbach BK, et al. Among authors: wittinghofer a. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10322-7. doi: 10.1073/pnas.1203223109. Epub 2012 Jun 11. Proc Natl Acad Sci U S A. 2012. PMID: 22689969 Free PMC article.

3

Revisiting the Roco G-protein cycle.

Terheyden S, Ho FY, Gilsbach BK, Wittinghofer A, Kortholt A. Terheyden S, et al. Among authors: wittinghofer a. Biochem J. 2015 Jan 1;465(1):139-47. doi: 10.1042/BJ20141095. Biochem J. 2015. PMID: 25317655

4

Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations.

Rudi K, Ho FY, Gilsbach BK, Pots H, Wittinghofer A, Kortholt A, Klare JP. Rudi K, et al. Among authors: wittinghofer a. Biosci Rep. 2015 Aug 26;35(5):e00254. doi: 10.1042/BSR20150128. Biosci Rep. 2015. PMID: 26310572 Free PMC article.

5

Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase.

Gotthardt K, Weyand M, Kortholt A, Van Haastert PJ, Wittinghofer A. Gotthardt K, et al. Among authors: wittinghofer a. EMBO J. 2008 Aug 20;27(16):2239-49. doi: 10.1038/emboj.2008.150. Epub 2008 Jul 24. EMBO J. 2008. PMID: 18650931 Free PMC article.

6

Biochemical and kinetic properties of the complex Roco G-protein cycle.

Wauters L, Terheyden S, Gilsbach BK, Leemans M, Athanasopoulos PS, Guaitoli G, Wittinghofer A, Gloeckner CJ, Versées W, Kortholt A. Wauters L, et al. Among authors: wittinghofer a. Biol Chem. 2018 Nov 27;399(12):1447-1456. doi: 10.1515/hsz-2018-0227. Biol Chem. 2018. PMID: 30067506

7

Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction.

Gremer L, Gilsbach B, Ahmadian MR, Wittinghofer A. Gremer L, et al. Among authors: wittinghofer a. Biol Chem. 2008 Sep;389(9):1163-71. doi: 10.1515/BC.2008.132. Biol Chem. 2008. PMID: 18713003

8

Characterization of the GbpD-activated Rap1 pathway regulating adhesion and cell polarity in Dictyostelium discoideum.

Kortholt A, Rehmann H, Kae H, Bosgraaf L, Keizer-Gunnink I, Weeks G, Wittinghofer A, Van Haastert PJ. Kortholt A, et al. Among authors: wittinghofer a. J Biol Chem. 2006 Aug 18;281(33):23367-76. doi: 10.1074/jbc.M600804200. Epub 2006 Jun 12. J Biol Chem. 2006. PMID: 16769729 Free article.

9

A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected].

Kortholt A, Bolourani P, Rehmann H, Keizer-Gunnink I, Weeks G, Wittinghofer A, Van Haastert PJ. Kortholt A, et al. Among authors: wittinghofer a. Mol Biol Cell. 2010 Mar 15;21(6):936-45. doi: 10.1091/mbc.e09-03-0177. Epub 2010 Jan 20. Mol Biol Cell. 2010. PMID: 20089846 Free PMC article.

10

Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site.

Zimmermann G, Schultz-Fademrecht C, Küchler P, Murarka S, Ismail S, Triola G, Nussbaumer P, Wittinghofer A, Waldmann H. Zimmermann G, et al. Among authors: wittinghofer a. J Med Chem. 2014 Jun 26;57(12):5435-48. doi: 10.1021/jm500632s. Epub 2014 Jun 11. J Med Chem. 2014. PMID: 24884780

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