Chen M - Search Results

1

Drug-induced liver injury: Interactions between drug properties and host factors.

Chen M, Suzuki A, Borlak J, Andrade RJ, Lucena MI. Chen M, et al. J Hepatol. 2015 Aug;63(2):503-14. doi: 10.1016/j.jhep.2015.04.016. Epub 2015 Apr 22. J Hepatol. 2015. PMID: 25912521 Free article. Review.

2

FDA-approved drug labeling for the study of drug-induced liver injury.

Chen M, Vijay V, Shi Q, Liu Z, Fang H, Tong W. Chen M, et al. Drug Discov Today. 2011 Aug;16(15-16):697-703. doi: 10.1016/j.drudis.2011.05.007. Epub 2011 May 20. Drug Discov Today. 2011. PMID: 21624500

3

Is toxicogenomics a more reliable and sensitive biomarker than conventional indicators from rats to predict drug-induced liver injury in humans?

Zhang M, Chen M, Tong W. Zhang M, et al. Among authors: chen m. Chem Res Toxicol. 2012 Jan 13;25(1):122-9. doi: 10.1021/tx200320e. Epub 2011 Dec 13. Chem Res Toxicol. 2012. PMID: 22122743

4

A decade of toxicogenomic research and its contribution to toxicological science.

Chen M, Zhang M, Borlak J, Tong W. Chen M, et al. Toxicol Sci. 2012 Dec;130(2):217-28. doi: 10.1093/toxsci/kfs223. Epub 2012 Jul 12. Toxicol Sci. 2012. PMID: 22790972 Review.

5

High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury.

Chen M, Borlak J, Tong W. Chen M, et al. Hepatology. 2013 Jul;58(1):388-96. doi: 10.1002/hep.26208. Epub 2013 May 27. Hepatology. 2013. PMID: 23258593

6

A unifying ontology to integrate histological and clinical observations for drug-induced liver injury.

Wang Y, Lin Z, Liu Z, Harris S, Kelly R, Zhang J, Ge W, Chen M, Borlak J, Tong W. Wang Y, et al. Among authors: chen m. Am J Pathol. 2013 Apr;182(4):1180-7. doi: 10.1016/j.ajpath.2012.12.033. Epub 2013 Feb 8. Am J Pathol. 2013. PMID: 23395088 Free article.

7

Quantitative structure-activity relationship models for predicting drug-induced liver injury based on FDA-approved drug labeling annotation and using a large collection of drugs.

Chen M, Hong H, Fang H, Kelly R, Zhou G, Borlak J, Tong W. Chen M, et al. Toxicol Sci. 2013 Nov;136(1):242-9. doi: 10.1093/toxsci/kft189. Epub 2013 Aug 31. Toxicol Sci. 2013. PMID: 23997115

8

High daily dose and being a substrate of cytochrome P450 enzymes are two important predictors of drug-induced liver injury.

Yu K, Geng X, Chen M, Zhang J, Wang B, Ilic K, Tong W. Yu K, et al. Among authors: chen m. Drug Metab Dispos. 2014 Apr;42(4):744-50. doi: 10.1124/dmd.113.056267. Epub 2014 Jan 24. Drug Metab Dispos. 2014. PMID: 24464804

9

Toward predictive models for drug-induced liver injury in humans: are we there yet?

Chen M, Bisgin H, Tong L, Hong H, Fang H, Borlak J, Tong W. Chen M, et al. Biomark Med. 2014;8(2):201-13. doi: 10.2217/bmm.13.146. Biomark Med. 2014. PMID: 24521015 Free article. Review.

10

Predicting idiosyncratic drug-induced liver injury: some recent advances.

Chen M, Borlak J, Tong W. Chen M, et al. Expert Rev Gastroenterol Hepatol. 2014 Sep;8(7):721-3. doi: 10.1586/17474124.2014.922871. Epub 2014 May 23. Expert Rev Gastroenterol Hepatol. 2014. PMID: 24857265

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