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459 results

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Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.
Xiang Y, Stine ZE, Xia J, Lu Y, O'Connor RS, Altman BJ, Hsieh AL, Gouw AM, Thomas AG, Gao P, Sun L, Song L, Yan B, Slusher BS, Zhuo J, Ooi LL, Lee CG, Mancuso A, McCallion AS, Le A, Milone MC, Rayport S, Felsher DW, Dang CV. Xiang Y, et al. Among authors: thomas ag. J Clin Invest. 2015 Jun;125(6):2293-306. doi: 10.1172/JCI75836. Epub 2015 Apr 27. J Clin Invest. 2015. PMID: 25915584 Free PMC article.
Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models.
Ghadge GD, Slusher BS, Bodner A, Canto MD, Wozniak K, Thomas AG, Rojas C, Tsukamoto T, Majer P, Miller RJ, Monti AL, Roos RP. Ghadge GD, et al. Among authors: thomas ag. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9554-9. doi: 10.1073/pnas.1530168100. Epub 2003 Jul 22. Proc Natl Acad Sci U S A. 2003. PMID: 12876198 Free PMC article.
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.
Seltzer MJ, Bennett BD, Joshi AD, Gao P, Thomas AG, Ferraris DV, Tsukamoto T, Rojas CJ, Slusher BS, Rabinowitz JD, Dang CV, Riggins GJ. Seltzer MJ, et al. Among authors: thomas ag. Cancer Res. 2010 Nov 15;70(22):8981-7. doi: 10.1158/0008-5472.CAN-10-1666. Epub 2010 Nov 2. Cancer Res. 2010. PMID: 21045145 Free PMC article.
Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice.
Rais R, Thomas AG, Wozniak K, Wu Y, Jaaro-Peled H, Sawa A, Strick CA, Engle SJ, Brandon NJ, Rojas C, Slusher BS, Tsukamoto T. Rais R, et al. Among authors: thomas ag. Drug Metab Dispos. 2012 Nov;40(11):2067-73. doi: 10.1124/dmd.112.046482. Epub 2012 Jul 26. Drug Metab Dispos. 2012. PMID: 22837388 Free PMC article.
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
Shukla K, Ferraris DV, Thomas AG, Stathis M, Duvall B, Delahanty G, Alt J, Rais R, Rojas C, Gao P, Xiang Y, Dang CV, Slusher BS, Tsukamoto T. Shukla K, et al. Among authors: thomas ag. J Med Chem. 2012 Dec 13;55(23):10551-63. doi: 10.1021/jm301191p. Epub 2012 Nov 30. J Med Chem. 2012. PMID: 23151085 Free PMC article.
459 results