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Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins.
MacNulty EE, McClue SJ, Carr IC, Jess T, Wakelam MJ, Milligan G. MacNulty EE, et al. Among authors: milligan g. J Biol Chem. 1992 Feb 5;267(4):2149-56. J Biol Chem. 1992. PMID: 1346392 Free article.
We have demonstrated recently in cells of one of these clones (1C) that the alpha 2-C10 receptor interacts directly with two distinct pertussis toxin-sensitive G-proteins, Gi2 and Gi3 (Milligan, G., Carr, C., Gould, G. W., Mullaney, I., and Lavan, B.E. …
We have demonstrated recently in cells of one of these clones (1C) that the alpha 2-C10 receptor interacts directly with two distinct pertus …
Agonist activation of transfected human M1 muscarinic acetylcholine receptors in CHO cells results in down-regulation of both the receptor and the alpha subunit of the G-protein Gq.
Mullaney I, Dodd MW, Buckley N, Milligan G. Mullaney I, et al. Among authors: milligan g. Biochem J. 1993 Jan 1;289 ( Pt 1)(Pt 1):125-31. doi: 10.1042/bj2890125. Biochem J. 1993. PMID: 8424750 Free PMC article.
A small decrease in levels of G-protein beta-subunit was also produced. Parallel assessment of agonist-induced down-regulation of the HM1 receptor demonstrated that it was lost in concert with the G-protein. ...We have previously noted that cellular levels of both G …
A small decrease in levels of G-protein beta-subunit was also produced. Parallel assessment of agonist-induced down-regulation of the …
Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry.
Burt AR, Sautel M, Wilson MA, Rees S, Wise A, Milligan G. Burt AR, et al. Among authors: milligan g. J Biol Chem. 1998 Apr 24;273(17):10367-75. doi: 10.1074/jbc.273.17.10367. J Biol Chem. 1998. PMID: 9553093 Free article.
792 results