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Page 1
The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state.
Adhikary T, Wortmann A, Schumann T, Finkernagel F, Lieber S, Roth K, Toth PM, Diederich WE, Nist A, Stiewe T, Kleinesudeik L, Reinartz S, Müller-Brüsselbach S, Müller R. Adhikary T, et al. Among authors: toth pm. Nucleic Acids Res. 2015 May 26;43(10):5033-51. doi: 10.1093/nar/gkv331. Epub 2015 Apr 30. Nucleic Acids Res. 2015. PMID: 25934804 Free PMC article.
Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion.
Adhikary T, Brandt DT, Kaddatz K, Stockert J, Naruhn S, Meissner W, Finkernagel F, Obert J, Lieber S, Scharfe M, Jarek M, Toth PM, Scheer F, Diederich WE, Reinartz S, Grosse R, Müller-Brüsselbach S, Müller R. Adhikary T, et al. Among authors: toth pm. Oncogene. 2013 Oct 31;32(44):5241-52. doi: 10.1038/onc.2012.549. Epub 2012 Dec 3. Oncogene. 2013. PMID: 23208498 Free PMC article.
Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment.
Schumann T, Adhikary T, Wortmann A, Finkernagel F, Lieber S, Schnitzer E, Legrand N, Schober Y, Nockher WA, Toth PM, Diederich WE, Nist A, Stiewe T, Wagner U, Reinartz S, Müller-Brüsselbach S, Müller R. Schumann T, et al. Among authors: toth pm. Oncotarget. 2015 May 30;6(15):13416-33. doi: 10.18632/oncotarget.3826. Oncotarget. 2015. PMID: 25968567 Free PMC article.
Development of improved PPARβ/δ inhibitors.
Toth PM, Naruhn S, Pape VF, Dörr SM, Klebe G, Müller R, Diederich WE. Toth PM, et al. ChemMedChem. 2012 Jan 2;7(1):159-70. doi: 10.1002/cmdc.201100408. Epub 2011 Oct 24. ChemMedChem. 2012. PMID: 22025402