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Functional magnetic resonance imaging analysis of food-related brain activity in patients with lipodystrophy undergoing leptin replacement therapy.
Aotani D, Ebihara K, Sawamoto N, Kusakabe T, Aizawa-Abe M, Kataoka S, Sakai T, Iogawa H, Ebihara C, Fujikura J, Hosoda K, Fukuyama H, Nakao K. Aotani D, et al. Among authors: sakai t. J Clin Endocrinol Metab. 2012 Oct;97(10):3663-71. doi: 10.1210/jc.2012-1872. Epub 2012 Aug 7. J Clin Endocrinol Metab. 2012. PMID: 22872692 Free PMC article. Clinical Trial.
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and α1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K. Miyamoto L, et al. Among authors: sakai t. J Biol Chem. 2012 Nov 23;287(48):40441-7. doi: 10.1074/jbc.M112.384545. Epub 2012 Sep 28. J Biol Chem. 2012. PMID: 23024365 Free PMC article.
Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver.
Aizawa-Abe M, Ebihara K, Ebihara C, Mashimo T, Takizawa A, Tomita T, Kusakabe T, Yamamoto Y, Aotani D, Yamamoto-Kataoka S, Sakai T, Hosoda K, Serikawa T, Nakao K. Aizawa-Abe M, et al. Among authors: sakai t. Physiol Genomics. 2013 Sep 3;45(17):786-93. doi: 10.1152/physiolgenomics.00040.2013. Epub 2013 Jun 25. Physiol Genomics. 2013. PMID: 23800849
Leptin improves fatty liver independently of insulin sensitization and appetite suppression in hepatocyte-specific Pten-deficient mice with insulin hypersensitivity.
Yamamoto-Kataoka S, Ebihara K, Aizawa-Abe M, Nishio M, Kusakabe T, Yamamoto Y, Aotani D, Sakai T, Zhao M, Ebihara C, Gumbilai VM, Hosoda K, Suzuki A, Nakao K. Yamamoto-Kataoka S, et al. Among authors: sakai t. Horm Metab Res. 2015 Mar;47(3):168-75. doi: 10.1055/s-0034-1395531. Epub 2014 Nov 21. Horm Metab Res. 2015. PMID: 25415231
Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet.
Sakai T, Kusakabe T, Ebihara K, Aotani D, Yamamoto-Kataoka S, Zhao M, Gumbilai VM, Ebihara C, Aizawa-Abe M, Yamamoto Y, Noguchi M, Fujikura J, Hosoda K, Inagaki N, Nakao K. Sakai T, et al. Am J Physiol Endocrinol Metab. 2014 Oct 15;307(8):E712-9. doi: 10.1152/ajpendo.00272.2014. Epub 2014 Aug 26. Am J Physiol Endocrinol Metab. 2014. PMID: 25159327 Free article.
5,736 results