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Page 1
Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.
Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. Takizawa H, et al. Among authors: eto k. J Clin Invest. 2010 Jan;120(1):179-90. doi: 10.1172/JCI39503. Epub 2009 Dec 21. J Clin Invest. 2010. PMID: 20038804 Free PMC article.
Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.
Suzuki-Inoue K, Inoue O, Ding G, Nishimura S, Hokamura K, Eto K, Kashiwagi H, Tomiyama Y, Yatomi Y, Umemura K, Shin Y, Hirashima M, Ozaki Y. Suzuki-Inoue K, et al. Among authors: eto k. J Biol Chem. 2010 Aug 6;285(32):24494-507. doi: 10.1074/jbc.M110.130575. Epub 2010 Jun 4. J Biol Chem. 2010. PMID: 20525685 Free PMC article.
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.
Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K. Takayama N, et al. Among authors: eto k. J Exp Med. 2010 Dec 20;207(13):2817-30. doi: 10.1084/jem.20100844. Epub 2010 Nov 22. J Exp Med. 2010. PMID: 21098095 Free PMC article.
Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia.
Kunishima S, Kashiwagi H, Otsu M, Takayama N, Eto K, Onodera M, Miyajima Y, Takamatsu Y, Suzumiya J, Matsubara K, Tomiyama Y, Saito H. Kunishima S, et al. Among authors: eto k. Blood. 2011 May 19;117(20):5479-84. doi: 10.1182/blood-2010-12-323691. Epub 2011 Mar 31. Blood. 2011. PMID: 21454453 Free article.
In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.
Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich BG, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R. Nishimura S, et al. Among authors: eto k. Blood. 2012 Feb 23;119(8):e45-56. doi: 10.1182/blood-2011-09-381400. Epub 2011 Nov 16. Blood. 2012. PMID: 22096246 Free PMC article.
949 results