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Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.
Henry JR, Kaufman MD, Peng SB, Ahn YM, Caldwell TM, Vogeti L, Telikepalli H, Lu WP, Hood MM, Rutkoski TJ, Smith BD, Vogeti S, Miller D, Wise SC, Chun L, Zhang X, Zhang Y, Kays L, Hipskind PA, Wrobleski AD, Lobb KL, Clay JM, Cohen JD, Walgren JL, McCann D, Patel P, Clawson DK, Guo S, Manglicmot D, Groshong C, Logan C, Starling JJ, Flynn DL. Henry JR, et al. Among authors: cohen jd. J Med Chem. 2015 May 28;58(10):4165-79. doi: 10.1021/acs.jmedchem.5b00067. Epub 2015 May 12. J Med Chem. 2015. PMID: 25965804
Imlunestrant is an Oral, Brain-Penetrant Selective Estrogen Receptor Degrader with Potent Antitumor Activity in ESR1 Wildtype and Mutant Breast Cancer.
Bhagwat SV, Mur C, Vandekopple M, Zhao B, Shen W, Marugán C, Capen A, Kindler L, Stephens JR, Huber L, Castanares MA, Garcia-Tapia D, Cohen JD, Bastian J, Mattioni B, Yuen E, Baker TK, Rodriguez Cruz V, Fei D, Manro JR, Pulliam N, Dowless MS, Ortiz Ruiz MJ, Yu C, Puca L, Klippel A, Bacchion F, Ismail-Khan R, Rodrik-Outmezguine V, Peng SB, Lallena MJ, Gong X, de Dios A. Bhagwat SV, et al. Among authors: cohen jd. Cancer Res. 2024 Dec 9. doi: 10.1158/0008-5472.CAN-24-2608. Online ahead of print. Cancer Res. 2024. PMID: 39652577
Detection of human brain cancers using genomic and immune cell characterization of cerebrospinal fluid through CSF-BAM.
Pearlman AH, Wang Y, Kalluri A, Parker M, Cohen JD, Dudley J, Rincon-Torroella J, Xia Y, Gensler R, Horwitz MA, Theodore J, Dobbyn L, Popoli M, Ptak J, Silliman N, Judge K, Groves M, Jackson CM, Jackson EM, Jallo GI, Lim M, Luciano M, Mukherjee D, Naidoo J, Rozati S, Sterling CH, Weingart J, Koschmann C, Mansoori A, Glantz M, Kamson D, Schreck KC, Pardo CA, Holdhoff M, Paul S, Kinzler KW, Papadopoulos N, Vogelstein B, Douville C, Bettegowda C. Pearlman AH, et al. Among authors: cohen jd. medRxiv [Preprint]. 2024 Dec 4:2024.12.02.24318303. doi: 10.1101/2024.12.02.24318303. medRxiv. 2024. PMID: 39677487 Free PMC article. Preprint.
Sculpting new visual categories into the human brain.
Iordan CR, Ritvo VJH, Norman KA, Turk-Browne NB, Cohen JD. Iordan CR, et al. Among authors: cohen jd. Proc Natl Acad Sci U S A. 2024 Dec 10;121(50):e2410445121. doi: 10.1073/pnas.2410445121. Epub 2024 Dec 3. Proc Natl Acad Sci U S A. 2024. PMID: 39625982 Free PMC article.
Humans actively reconfigure neural task states.
Ritz H, Jha A, Pillow J, Daw ND, Cohen JD. Ritz H, et al. Among authors: cohen jd. bioRxiv [Preprint]. 2024 Oct 13:2024.09.29.615736. doi: 10.1101/2024.09.29.615736. bioRxiv. 2024. PMID: 39416099 Free PMC article. Preprint.
Multimodal evidence for cerebellar influence on cortical development in autism: structural growth amidst functional disruption.
d'Oleire Uquillas F, Sefik E, Li B, Trotter MA, Steele KA, Seidlitz J, Gesue R, Latif M, Fasulo T, Zhang V, Kislin M, Verpeut JL, Cohen JD, Sepulcre J, Wang SS, Gomez J. d'Oleire Uquillas F, et al. Among authors: cohen jd. Mol Psychiatry. 2024 Oct 11. doi: 10.1038/s41380-024-02769-1. Online ahead of print. Mol Psychiatry. 2024. PMID: 39390225
761 results