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Page 1
Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.
Henry JR, Kaufman MD, Peng SB, Ahn YM, Caldwell TM, Vogeti L, Telikepalli H, Lu WP, Hood MM, Rutkoski TJ, Smith BD, Vogeti S, Miller D, Wise SC, Chun L, Zhang X, Zhang Y, Kays L, Hipskind PA, Wrobleski AD, Lobb KL, Clay JM, Cohen JD, Walgren JL, McCann D, Patel P, Clawson DK, Guo S, Manglicmot D, Groshong C, Logan C, Starling JJ, Flynn DL. Henry JR, et al. Among authors: telikepalli h. J Med Chem. 2015 May 28;58(10):4165-79. doi: 10.1021/acs.jmedchem.5b00067. Epub 2015 May 12. J Med Chem. 2015. PMID: 25965804
Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2.
Smith BD, Kaufman MD, Leary CB, Turner BA, Wise SC, Ahn YM, Booth RJ, Caldwell TM, Ensinger CL, Hood MM, Lu WP, Patt TW, Patt WC, Rutkoski TJ, Samarakoon T, Telikepalli H, Vogeti L, Vogeti S, Yates KM, Chun L, Stewart LJ, Clare M, Flynn DL. Smith BD, et al. Among authors: telikepalli h. Mol Cancer Ther. 2015 Sep;14(9):2023-34. doi: 10.1158/1535-7163.MCT-14-1105. Epub 2015 Aug 18. Mol Cancer Ther. 2015. PMID: 26285778
Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants.
Smith BD, Kaufman MD, Lu WP, Gupta A, Leary CB, Wise SC, Rutkoski TJ, Ahn YM, Al-Ani G, Bulfer SL, Caldwell TM, Chun L, Ensinger CL, Hood MM, McKinley A, Patt WC, Ruiz-Soto R, Su Y, Telikepalli H, Town A, Turner BA, Vogeti L, Vogeti S, Yates K, Janku F, Abdul Razak AR, Rosen O, Heinrich MC, Flynn DL. Smith BD, et al. Among authors: telikepalli h. Cancer Cell. 2019 May 13;35(5):738-751.e9. doi: 10.1016/j.ccell.2019.04.006. Cancer Cell. 2019. PMID: 31085175 Free article.
Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036.
Chan WW, Wise SC, Kaufman MD, Ahn YM, Ensinger CL, Haack T, Hood MM, Jones J, Lord JW, Lu WP, Miller D, Patt WC, Smith BD, Petillo PA, Rutkoski TJ, Telikepalli H, Vogeti L, Yao T, Chun L, Clark R, Evangelista P, Gavrilescu LC, Lazarides K, Zaleskas VM, Stewart LJ, Van Etten RA, Flynn DL. Chan WW, et al. Among authors: telikepalli h. Cancer Cell. 2011 Apr 12;19(4):556-68. doi: 10.1016/j.ccr.2011.03.003. Cancer Cell. 2011. PMID: 21481795 Free PMC article.
The search for orally active medications through combinatorial chemistry.
Fecik RA, Frank KE, Gentry EJ, Menon SR, Mitscher LA, Telikepalli H. Fecik RA, et al. Among authors: telikepalli h. Med Res Rev. 1998 May;18(3):149-85. doi: 10.1002/(sici)1098-1128(199805)18:3<149::aid-med2>3.0.co;2-x. Med Res Rev. 1998. PMID: 9578985 Review.
Pyrazinetetracarboxamide: A Duplex Ligand for Palladium(II).
Lohrman J, Telikepalli H, Johnson TS, Jackson TA, Day VW, Bowman-James K. Lohrman J, et al. Among authors: telikepalli h. Inorg Chem. 2016 Jun 6;55(11):5098-100. doi: 10.1021/acs.inorgchem.6b00594. Epub 2016 May 17. Inorg Chem. 2016. PMID: 27187158
Hydrophilic and hydrophobic carboxamide pincers as anion hosts.
Lohrman J, Pramanik S, Kaur S, Telikepalli H, Day VW, Bowman-James K. Lohrman J, et al. Among authors: telikepalli h. Org Biomol Chem. 2021 Oct 14;19(39):8516-8520. doi: 10.1039/d1ob01605a. Org Biomol Chem. 2021. PMID: 34553743
Antimutagenicity of secondary metabolites from higher plants.
Mitscher LA, Telikepalli H, Wang PB, Kuo S, Shankel DM, Stewart G. Mitscher LA, et al. Among authors: telikepalli h. Mutat Res. 1992 Jun;267(2):229-41. doi: 10.1016/0027-5107(92)90067-c. Mutat Res. 1992. PMID: 1376425 Review.
18 results