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BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells.
Coudé MM, Braun T, Berrou J, Dupont M, Bertrand S, Masse A, Raffoux E, Itzykson R, Delord M, Riveiro ME, Herait P, Baruchel A, Dombret H, Gardin C. Coudé MM, et al. Among authors: berrou j. Oncotarget. 2015 Jul 10;6(19):17698-712. doi: 10.18632/oncotarget.4131. Oncotarget. 2015. PMID: 25989842 Free PMC article.
BET inhibitors impair leukemic stem cell function only in defined oncogenic subgroups of acute myeloid leukaemias.
Massé A, Roulin L, Pasanisi J, Penneroux J, Gachet S, Delord M, Ali A, Alberdi A, Berrou J, Passet M, Hernandez L, Quentin S, Gardin C, Raffoux E, Adès L, Braun T, Soulier J, Clappier E, Dombret H, Puissant A, Itzykson R. Massé A, et al. Among authors: berrou j. Leuk Res. 2019 Dec;87:106269. doi: 10.1016/j.leukres.2019.106269. Epub 2019 Nov 7. Leuk Res. 2019. PMID: 31751766
Biological Effects of BET Inhibition by OTX015 (MK-8628) and JQ1 in NPM1-Mutated (NPM1c) Acute Myeloid Leukemia (AML).
Djamai H, Berrou J, Dupont M, Coudé MM, Delord M, Clappier E, Marceau-Renaut A, Kaci A, Raffoux E, Itzykson R, Berthier C, Wu HC, Hleihel R, Bazarbachi A, de Thé H, Baruchel A, Gardin C, Dombret H, Braun T. Djamai H, et al. Among authors: berrou j. Biomedicines. 2021 Nov 17;9(11):1704. doi: 10.3390/biomedicines9111704. Biomedicines. 2021. PMID: 34829934 Free PMC article.
Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia.
Pardieu B, Pasanisi J, Ling F, Dal Bello R, Penneroux J, Su A, Joudinaud R, Chat L, Wu HC, Duchmann M, Sodaro G, Chauvel C, Castelli FA, Vasseur L, Pacchiardi K, Belloucif Y, Laiguillon MC, Meduri E, Vaganay C, Alexe G, Berrou J, Benaksas C, Forget A, Braun T, Gardin C, Raffoux E, Clappier E, Adès L, de Thé H, Fenaille F, Huntly BJ, Stegmaier K, Dombret H, Fenouille N, Lobry C, Puissant A, Itzykson R. Pardieu B, et al. Among authors: berrou j. Leukemia. 2022 Jun;36(6):1585-1595. doi: 10.1038/s41375-022-01573-6. Epub 2022 Apr 26. Leukemia. 2022. PMID: 35474100
A multiparametric niche-like drug screening platform in acute myeloid leukemia.
Dal Bello R, Pasanisi J, Joudinaud R, Duchmann M, Pardieu B, Ayaka P, Di Feo G, Sodaro G, Chauvel C, Kim R, Vasseur L, Chat L, Ling F, Pacchiardi K, Vaganay C, Berrou J, Benaksas C, Boissel N, Braun T, Preudhomme C, Dombret H, Raffoux E, Fenouille N, Clappier E, Adès L, Puissant A, Itzykson R. Dal Bello R, et al. Among authors: berrou j. Blood Cancer J. 2022 Jun 24;12(6):95. doi: 10.1038/s41408-022-00689-3. Blood Cancer J. 2022. PMID: 35750691 Free PMC article.
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