Denko N - Search Results

1

The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation.

Cerniglia GJ, Dey S, Gallagher-Colombo SM, Daurio NA, Tuttle S, Busch TM, Lin A, Sun R, Esipova TV, Vinogradov SA, Denko N, Koumenis C, Maity A. Cerniglia GJ, et al. Among authors: denko n. Mol Cancer Ther. 2015 Aug;14(8):1928-38. doi: 10.1158/1535-7163.MCT-14-0888. Epub 2015 May 20. Mol Cancer Ther. 2015. PMID: 25995437 Free PMC article.

2

Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2).

Koong AC, Chen EY, Mivechi NF, Denko NC, Stambrook P, Giaccia AJ. Koong AC, et al. Among authors: denko nc. Cancer Res. 1994 Oct 15;54(20):5273-9. Cancer Res. 1994. PMID: 7923153

3

Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

Papandreou I, Goliasova T, Denko NC. Papandreou I, et al. Int J Cancer. 2011 Mar 1;128(5):1001-8. doi: 10.1002/ijc.25728. Epub 2010 Dec 7. Int J Cancer. 2011. PMID: 20957634

4

Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth.

Sun RC, Denko NC. Sun RC, et al. Cell Metab. 2014 Feb 4;19(2):285-92. doi: 10.1016/j.cmet.2013.11.022. Cell Metab. 2014. PMID: 24506869 Free PMC article.

5

Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.

Jiang D, Tam AB, Alagappan M, Hay MP, Gupta A, Kozak MM, Solow-Cordero DE, Lum PY, Denko NC, Giaccia AJ, Le QT, Niwa M, Koong AC. Jiang D, et al. Mol Cancer Ther. 2016 Sep;15(9):2055-65. doi: 10.1158/1535-7163.MCT-15-1023. Epub 2016 Jun 15. Mol Cancer Ther. 2016. PMID: 27307600 Free PMC article.

6

Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells.

Sun RC, Koong A, Giaccia A, Denko NC. Sun RC, et al. Adv Exp Med Biol. 2016;899:113-20. doi: 10.1007/978-3-319-26666-4_7. Adv Exp Med Biol. 2016. PMID: 27325264 Free PMC article.

7

Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours.

Golias T, Papandreou I, Sun R, Kumar B, Brown NV, Swanson BJ, Pai R, Jaitin D, Le QT, Teknos TN, Denko NC. Golias T, et al. Among authors: denko nc. Sci Rep. 2016 Aug 8;6:31146. doi: 10.1038/srep31146. Sci Rep. 2016. PMID: 27498883 Free PMC article.

8

A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation.

Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC. Yang Z, et al. Mol Cancer Res. 2018 May;16(5):745-753. doi: 10.1158/1541-7786.MCR-17-0307. Epub 2018 Feb 9. Mol Cancer Res. 2018. PMID: 29440447 Free PMC article.

9

HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors.

VandeKopple MJ, Wu J, Auer EN, Giaccia AJ, Denko NC, Papandreou I. VandeKopple MJ, et al. Among authors: denko nc. Mol Cancer Res. 2019 Oct;17(10):2089-2101. doi: 10.1158/1541-7786.MCR-18-1343. Epub 2019 Jul 15. Mol Cancer Res. 2019. PMID: 31308147 Free PMC article.

10

Hypoxia links ATR and p53 through replication arrest.

Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. Hammond EM, et al. Mol Cell Biol. 2002 Mar;22(6):1834-43. doi: 10.1128/MCB.22.6.1834-1843.2002. Mol Cell Biol. 2002. PMID: 11865061 Free PMC article.

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