Koumenis C - Search Results

1

The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation.

Cerniglia GJ, Dey S, Gallagher-Colombo SM, Daurio NA, Tuttle S, Busch TM, Lin A, Sun R, Esipova TV, Vinogradov SA, Denko N, Koumenis C, Maity A. Cerniglia GJ, et al. Among authors: koumenis c. Mol Cancer Ther. 2015 Aug;14(8):1928-38. doi: 10.1158/1535-7163.MCT-14-0888. Epub 2015 May 20. Mol Cancer Ther. 2015. PMID: 25995437 Free PMC article.

2

HIF and MIF--a nifty way to delay senescence?

Maity A, Koumenis C. Maity A, et al. Among authors: koumenis c. Genes Dev. 2006 Dec 15;20(24):3337-41. doi: 10.1101/gad.1506906. Genes Dev. 2006. PMID: 17182862 Free article. No abstract available.

3

The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway.

Javvadi P, Segan AT, Tuttle SW, Koumenis C. Javvadi P, et al. Among authors: koumenis c. Mol Pharmacol. 2008 May;73(5):1491-501. doi: 10.1124/mol.107.043554. Epub 2008 Feb 5. Mol Pharmacol. 2008. PMID: 18252805 Free PMC article.

4

Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells.

Javvadi P, Hertan L, Kosoff R, Datta T, Kolev J, Mick R, Tuttle SW, Koumenis C. Javvadi P, et al. Among authors: koumenis c. Cancer Res. 2010 Mar 1;70(5):1941-50. doi: 10.1158/0008-5472.CAN-09-3025. Epub 2010 Feb 16. Cancer Res. 2010. PMID: 20160040 Free PMC article.

5

Location, location, location-makes all the difference for hypoxia in lung tumors.

Maity A, Koumenis C. Maity A, et al. Among authors: koumenis c. Clin Cancer Res. 2010 Oct 1;16(19):4685-7. doi: 10.1158/1078-0432.CCR-10-2004. Epub 2010 Sep 21. Clin Cancer Res. 2010. PMID: 20858842 Free PMC article.

6

In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection.

Marotta D, Karar J, Jenkins WT, Kumanova M, Jenkins KW, Tobias JW, Baldwin D, Hatzigeorgiou A, Alexiou P, Evans SM, Alarcon R, Maity A, Koch C, Koumenis C. Marotta D, et al. Among authors: koumenis c. Cancer Res. 2011 Feb 1;71(3):779-89. doi: 10.1158/0008-5472.CAN-10-3061. Epub 2011 Jan 25. Cancer Res. 2011. PMID: 21266355 Free PMC article.

7

The chemopreventive and clinically used agent curcumin sensitizes HPV (-) but not HPV (+) HNSCC to ionizing radiation, in vitro and in a mouse orthotopic model.

Tuttle S, Hertan L, Daurio N, Porter S, Kaushick C, Li D, Myamoto S, Lin A, O'Malley BW, Koumenis C. Tuttle S, et al. Among authors: koumenis c. Cancer Biol Ther. 2012 May;13(7):575-84. doi: 10.4161/cbt.19772. Epub 2012 May 1. Cancer Biol Ther. 2012. PMID: 22441776 Free PMC article.

8

Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia.

Karar J, Cerniglia GJ, Lindsten T, Koumenis C, Maity A. Karar J, et al. Among authors: koumenis c. Cancer Biol Ther. 2012 Sep;13(11):1102-11. doi: 10.4161/cbt.21144. Epub 2012 Aug 16. Cancer Biol Ther. 2012. PMID: 22895065 Free PMC article.

9

Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.

Cerniglia GJ, Karar J, Tyagi S, Christofidou-Solomidou M, Rengan R, Koumenis C, Maity A. Cerniglia GJ, et al. Among authors: koumenis c. Mol Pharmacol. 2012 Dec;82(6):1230-40. doi: 10.1124/mol.112.080408. Epub 2012 Sep 18. Mol Pharmacol. 2012. PMID: 22989521 Free PMC article.

10

ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.

Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C. Hart LS, et al. Among authors: koumenis c. J Clin Invest. 2012 Dec;122(12):4621-34. doi: 10.1172/JCI62973. Epub 2012 Nov 12. J Clin Invest. 2012. PMID: 23143306 Free PMC article.

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