Vasquez G - Search Results

1

Efficient Synthesis and Biological Evaluation of 5'-GalNAc Conjugated Antisense Oligonucleotides.

Østergaard ME, Yu J, Kinberger GA, Wan WB, Migawa MT, Vasquez G, Schmidt K, Gaus HJ, Murray HM, Low A, Swayze EE, Prakash TP, Seth PP. Østergaard ME, et al. Among authors: vasquez g. Bioconjug Chem. 2015 Aug 19;26(8):1451-5. doi: 10.1021/acs.bioconjchem.5b00265. Epub 2015 Jun 10. Bioconjug Chem. 2015. PMID: 26011654

2

2'-O-[2-[N,N-(dialkyl)aminooxy]ethyl]-modified antisense oligonucleotides.

Prakash TP, Manoharan M, Kawasaki AM, Lesnik EA, Owens SR, Vasquez G. Prakash TP, et al. Among authors: vasquez g. Org Lett. 2000 Dec 14;2(25):3995-8. doi: 10.1021/ol006555g. Org Lett. 2000. PMID: 11112626

3

Synthesis of 2'-O-[2-[(N,N-dimethylamino)oxy]ethyl] modified nucleosides and oligonucleotides.

Prakash TP, Kawasaki AM, Fraser AS, Vasquez G, Manoharan M. Prakash TP, et al. Among authors: vasquez g. J Org Chem. 2002 Jan 25;67(2):357-69. doi: 10.1021/jo0103975. J Org Chem. 2002. PMID: 11798305

4

Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo.

Shen L, Siwkowski A, Wancewicz EV, Lesnik E, Butler M, Witchell D, Vasquez G, Ross B, Acevedo O, Inamati G, Sasmor H, Manoharan M, Monia BP. Shen L, et al. Among authors: vasquez g. Antisense Nucleic Acid Drug Dev. 2003;13(3):129-42. doi: 10.1089/108729003768247592. Antisense Nucleic Acid Drug Dev. 2003. PMID: 12954113

5

The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.

Lima WF, Rose JB, Nichols JG, Wu H, Migawa MT, Wyrzykiewicz TK, Vasquez G, Swayze EE, Crooke ST. Lima WF, et al. Among authors: vasquez g. Mol Pharmacol. 2007 Jan;71(1):73-82. doi: 10.1124/mol.106.025429. Epub 2006 Oct 6. Mol Pharmacol. 2007. PMID: 17028157

6

Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin.

Hanessian S, Szychowski J, Adhikari SS, Vasquez G, Kandasamy P, Swayze EE, Migawa MT, Ranken R, François B, Wirmer-Bartoschek J, Kondo J, Westhof E. Hanessian S, et al. Among authors: vasquez g. J Med Chem. 2007 May 17;50(10):2352-69. doi: 10.1021/jm061200+. Epub 2007 Apr 26. J Med Chem. 2007. PMID: 17458946

7

Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs.

Seth PP, Siwkowski A, Allerson CR, Vasquez G, Lee S, Prakash TP, Kinberger G, Migawa MT, Gaus H, Bhat B, Swayze EE. Seth PP, et al. Among authors: vasquez g. Nucleic Acids Symp Ser (Oxf). 2008;(52):553-4. doi: 10.1093/nass/nrn280. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776499

8

Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals.

Seth PP, Siwkowski A, Allerson CR, Vasquez G, Lee S, Prakash TP, Wancewicz EV, Witchell D, Swayze EE. Seth PP, et al. Among authors: vasquez g. J Med Chem. 2009 Jan 8;52(1):10-3. doi: 10.1021/jm801294h. J Med Chem. 2009. PMID: 19086780

9

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

Seth PP, Vasquez G, Allerson CA, Berdeja A, Gaus H, Kinberger GA, Prakash TP, Migawa MT, Bhat B, Swayze EE. Seth PP, et al. Among authors: vasquez g. J Org Chem. 2010 Mar 5;75(5):1569-81. doi: 10.1021/jo902560f. J Org Chem. 2010. PMID: 20136157

10

Configuration of the 5'-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides.

Seth PP, Allerson CR, Siwkowski A, Vasquez G, Berdeja A, Migawa MT, Gaus H, Prakash TP, Bhat B, Swayze EE. Seth PP, et al. Among authors: vasquez g. J Med Chem. 2010 Dec 9;53(23):8309-18. doi: 10.1021/jm101207e. Epub 2010 Nov 8. J Med Chem. 2010. PMID: 21058707

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