Castell JV - Search Results

1

LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells.

García-Cañaveras JC, Jiménez N, Gómez-Lechón MJ, Castell JV, Donato MT, Lahoz A. García-Cañaveras JC, et al. Among authors: castell jv. Electrophoresis. 2015 Sep;36(18):2294-2302. doi: 10.1002/elps.201500095. Epub 2015 Jul 22. Electrophoresis. 2015. PMID: 26031481

2

Cytometric analysis for drug-induced steatosis in HepG2 cells.

Donato MT, Martínez-Romero A, Jiménez N, Negro A, Herrera G, Castell JV, O'Connor JE, Gómez-Lechón MJ. Donato MT, et al. Among authors: castell jv. Chem Biol Interact. 2009 Oct 30;181(3):417-23. doi: 10.1016/j.cbi.2009.07.019. Epub 2009 Aug 6. Chem Biol Interact. 2009. PMID: 19647728

3

Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: focus on in vitro studies.

Donato MT, Castell JV. Donato MT, et al. Among authors: castell jv. Clin Pharmacokinet. 2003;42(2):153-78. doi: 10.2165/00003088-200342020-00004. Clin Pharmacokinet. 2003. PMID: 12537515 Review.

4

Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes.

Donato MT, Jiménez N, Castell JV, Gómez-Lechón MJ. Donato MT, et al. Among authors: castell jv. Drug Metab Dispos. 2004 Jul;32(7):699-706. doi: 10.1124/dmd.32.7.699. Drug Metab Dispos. 2004. PMID: 15205384

5

Transcriptional regulation and expression of CYP3A4 in hepatocytes.

Martínez-Jiménez CP, Jover R, Donato MT, Castell JV, Gómez-Lechón MJ. Martínez-Jiménez CP, et al. Among authors: castell jv. Curr Drug Metab. 2007 Feb;8(2):185-94. doi: 10.2174/138920007779815986. Curr Drug Metab. 2007. PMID: 17305497 Review.

6

An update on metabolism studies using human hepatocytes in primary culture.

Gómez-Lechón MJ, Castell JV, Donato MT. Gómez-Lechón MJ, et al. Among authors: castell jv. Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):837-54. doi: 10.1517/17425255.4.7.837. Expert Opin Drug Metab Toxicol. 2008. PMID: 18624674 Review.

7

Identification of apoptotic drugs: multiparametric evaluation in cultured hepatocytes.

Gómez-Lechón MJ, O'Connor JE, Lahoz A, Castell JV, Donato MT. Gómez-Lechón MJ, et al. Among authors: castell jv. Curr Med Chem. 2008;15(20):2071-85. doi: 10.2174/092986708785132861. Curr Med Chem. 2008. PMID: 18691057 Review.

8

Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies.

Donato MT, Montero S, Castell JV, Gómez-Lechón MJ, Lahoz A. Donato MT, et al. Among authors: castell jv. Anal Bioanal Chem. 2010 Mar;396(6):2251-63. doi: 10.1007/s00216-009-3441-1. Epub 2010 Feb 10. Anal Bioanal Chem. 2010. PMID: 20145913

9

Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo.

Donato MT, Hallifax D, Picazo L, Castell JV, Houston JB, Gomez-Lechón MJ, Lahoz A. Donato MT, et al. Among authors: castell jv. Drug Metab Dispos. 2010 Sep;38(9):1449-55. doi: 10.1124/dmd.110.033605. Epub 2010 May 25. Drug Metab Dispos. 2010. PMID: 20501911

10

The use of hepatocytes to investigate drug toxicity.

Gómez-Lechón MJ, Castell JV, Donato MT. Gómez-Lechón MJ, et al. Among authors: castell jv. Methods Mol Biol. 2010;640:389-415. doi: 10.1007/978-1-60761-688-7_21. Methods Mol Biol. 2010. PMID: 20645064

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