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A multicenter randomized open-label study of rituximab plus rhTPO vs rituximab in corticosteroid-resistant or relapsed ITP.
Zhou H, Xu M, Qin P, Zhang HY, Yuan CL, Zhao HG, Cui ZG, Meng YS, Wang L, Zhou F, Wang X, Li DQ, Bi KH, Zhu CS, Guo CS, Chu XX, Wu QC, Liu XG, Dong XY, Li J, Peng J, Hou M. Zhou H, et al. Among authors: xu m. Blood. 2015 Mar 5;125(10):1541-7. doi: 10.1182/blood-2014-06-581868. Epub 2015 Jan 9. Blood. 2015. PMID: 25575541 Free PMC article. Clinical Trial.
The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy.
Zhu G, Zhang Q, Reddy EC, Carrim N, Chen Y, Xu XR, Xu M, Wang Y, Hou Y, Ma L, Li Y, Rui M, Petruzziello-Pellegrini TN, Lavalle C, Stratton TW, Lei X, Adili R, Chen P, Zhu C, Wilkins JA, Hynes RO, Freedman J, Ni H. Zhu G, et al. Among authors: xu m, xu xr. Blood. 2017 Mar 30;129(13):1840-1854. doi: 10.1182/blood-2016-07-729400. Epub 2017 Jan 25. Blood. 2017. PMID: 28122739 Free PMC article.
GPIbα is required for platelet-mediated hepatic thrombopoietin generation.
Xu M, Li J, Neves MAD, Zhu G, Carrim N, Yu R, Gupta S, Marshall J, Rotstein O, Peng J, Hou M, Kunishima S, Ware J, Branch DR, Lazarus AH, Ruggeri ZM, Freedman J, Ni H. Xu M, et al. Blood. 2018 Aug 9;132(6):622-634. doi: 10.1182/blood-2017-12-820779. Epub 2018 May 24. Blood. 2018. PMID: 29794068 Free article.
Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis.
Xu XR, Wang Y, Adili R, Ju L, Spring CM, Jin JW, Yang H, Neves MAD, Chen P, Yang Y, Lei X, Chen Y, Gallant RC, Xu M, Zhang H, Song J, Ke P, Zhang D, Carrim N, Yu SY, Zhu G, She YM, Cyr T, Fu W, Liu G, Connelly PW, Rand ML, Adeli K, Freedman J, Lee JE, Tso P, Marchese P, Davidson WS, Jackson SP, Zhu C, Ruggeri ZM, Ni H. Xu XR, et al. Among authors: xu m. Nat Commun. 2018 Sep 6;9(1):3608. doi: 10.1038/s41467-018-05806-0. Nat Commun. 2018. PMID: 30190457 Free PMC article.
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