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Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases.
Vincetti P, Caporuscio F, Kaptein S, Gioiello A, Mancino V, Suzuki Y, Yamamoto N, Crespan E, Lossani A, Maga G, Rastelli G, Castagnolo D, Neyts J, Leyssen P, Costantino G, Radi M. Vincetti P, et al. Among authors: maga g. J Med Chem. 2015 Jun 25;58(12):4964-75. doi: 10.1021/acs.jmedchem.5b00108. Epub 2015 Jun 15. J Med Chem. 2015. PMID: 26039671
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity.
Campiani G, Morelli E, Fabbrini M, Nacci V, Greco G, Novellino E, Ramunno A, Maga G, Spadari S, Caliendo G, Bergamini A, Faggioli E, Uccella I, Bolacchi F, Marini S, Coletta M, Nacca A, Caccia S. Campiani G, et al. Among authors: maga g. J Med Chem. 1999 Oct 21;42(21):4462-70. doi: 10.1021/jm990150o. J Med Chem. 1999. PMID: 10543890
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.
Campiani G, Aiello F, Fabbrini M, Morelli E, Ramunno A, Armaroli S, Nacci V, Garofalo A, Greco G, Novellino E, Maga G, Spadari S, Bergamini A, Ventura L, Bongiovanni B, Capozzi M, Bolacchi F, Marini S, Coletta M, Guiso G, Caccia S. Campiani G, et al. Among authors: maga g. J Med Chem. 2001 Feb 1;44(3):305-15. doi: 10.1021/jm0010365. J Med Chem. 2001. PMID: 11462972
Drug resistance mutations in the nucleotide binding pocket of human immunodeficiency virus type 1 reverse transcriptase differentially affect the phosphorolysis-dependent primer unblocking activity in the presence of stavudine and zidovudine and its inhibition by efavirenz.
Crespan E, Locatelli GA, Cancio R, Hübscher U, Spadari S, Maga G. Crespan E, et al. Among authors: maga g. Antimicrob Agents Chemother. 2005 Jan;49(1):342-9. doi: 10.1128/AAC.49.1.342-349.2005. Antimicrob Agents Chemother. 2005. PMID: 15616314 Free PMC article.
Diketo hexenoic acid derivatives are novel selective non-nucleoside inhibitors of mammalian terminal deoxynucleotidyl transferases, with potent cytotoxic effect against leukemic cells.
Locatelli GA, Di Santo R, Crespan E, Costi R, Roux A, Hübscher U, Shevelev I, Blanca G, Villani G, Spadari S, Maga G. Locatelli GA, et al. Among authors: maga g. Mol Pharmacol. 2005 Aug;68(2):538-50. doi: 10.1124/mol.105.013326. Epub 2005 May 18. Mol Pharmacol. 2005. PMID: 15901847
264 results