Le SQ - Search Results

1

A novel, long-lived, and highly engraftable immunodeficient mouse model of mucopolysaccharidosis type I.

Mendez DC, Stover AE, Rangel AD, Brick DJ, Nethercott HE, Torres MA, Khalid O, Wong AM, Cooper JD, Jester JV, Monuki ES, McGuire C, Le SQ, Kan SH, Dickson PI, Schwartz PH. Mendez DC, et al. Among authors: le sq. Mol Ther Methods Clin Dev. 2015 Feb 11;2:14068. doi: 10.1038/mtm.2014.68. eCollection 2015. Mol Ther Methods Clin Dev. 2015. PMID: 26052536 Free PMC article.

2

Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I.

Kakkis E, McEntee M, Vogler C, Le S, Levy B, Belichenko P, Mobley W, Dickson P, Hanson S, Passage M. Kakkis E, et al. Mol Genet Metab. 2004 Sep-Oct;83(1-2):163-74. doi: 10.1016/j.ymgme.2004.07.003. Mol Genet Metab. 2004. PMID: 15464431

3

Intrathecal enzyme replacement therapy: successful treatment of brain disease via the cerebrospinal fluid.

Dickson P, McEntee M, Vogler C, Le S, Levy B, Peinovich M, Hanson S, Passage M, Kakkis E. Dickson P, et al. Mol Genet Metab. 2007 May;91(1):61-8. doi: 10.1016/j.ymgme.2006.12.012. Epub 2007 Feb 26. Mol Genet Metab. 2007. PMID: 17321776 Free PMC article.

4

Immune tolerance improves the efficacy of enzyme replacement therapy in canine mucopolysaccharidosis I.

Dickson P, Peinovich M, McEntee M, Lester T, Le S, Krieger A, Manuel H, Jabagat C, Passage M, Kakkis ED. Dickson P, et al. J Clin Invest. 2008 Aug;118(8):2868-76. doi: 10.1172/JCI34676. J Clin Invest. 2008. PMID: 18654665 Free PMC article.

5

Continuous infusion of enzyme replacement therapy is inferior to weekly infusions in MPS I dogs.

Passage MB, Krieger AW, Peinovich MC, Lester T, Le SQ, Dickson PI, Kakkis ED. Passage MB, et al. Among authors: le sq. J Inherit Metab Dis. 2009 Dec;32 Suppl 1(Suppl 1):S253-8. doi: 10.1007/s10545-009-1198-5. Epub 2009 Jun 28. J Inherit Metab Dis. 2009. PMID: 19562502 Free PMC article.

6

Early versus late treatment of spinal cord compression with long-term intrathecal enzyme replacement therapy in canine mucopolysaccharidosis type I.

Dickson PI, Hanson S, McEntee MF, Vite CH, Vogler CA, Mlikotic A, Chen AH, Ponder KP, Haskins ME, Tippin BL, Le SQ, Passage MB, Guerra C, Dierenfeld A, Jens J, Snella E, Kan SH, Ellinwood NM. Dickson PI, et al. Among authors: le sq. Mol Genet Metab. 2010 Oct-Nov;101(2-3):115-22. doi: 10.1016/j.ymgme.2010.06.020. Epub 2010 Jul 23. Mol Genet Metab. 2010. PMID: 20655780 Free PMC article.

7

Glycosaminoglycan storage in neuroanatomical regions of mucopolysaccharidosis I dogs following intrathecal recombinant human iduronidase.

Chen A, Vogler C, McEntee M, Hanson S, Ellinwood NM, Jens J, Snella E, Passage M, Le S, Guerra C, Dickson P. Chen A, et al. APMIS. 2011 Aug;119(8):513-21. doi: 10.1111/j.1600-0463.2011.02760.x. Epub 2011 May 14. APMIS. 2011. PMID: 21749451 Free PMC article.

8

Biochemical characterization of fluorescent-labeled recombinant human alpha-L-iduronidase in vitro.

Tippin BL, Troitskaya L, Kan SH, Todd AK, Le SQ, Dickson PI. Tippin BL, et al. Among authors: le sq. Biotechnol Appl Biochem. 2011 Nov-Dec;58(6):391-6. doi: 10.1002/bab.52. Epub 2011 Oct 28. Biotechnol Appl Biochem. 2011. PMID: 22172101 Free PMC article.

9

Specific antibody titer alters the effectiveness of intrathecal enzyme replacement therapy in canine mucopolysaccharidosis I.

Dickson PI, Ellinwood NM, Brown JR, Witt RG, Le SQ, Passage MB, Vera MU, Crawford BE. Dickson PI, et al. Among authors: le sq. Mol Genet Metab. 2012 May;106(1):68-72. doi: 10.1016/j.ymgme.2012.02.003. Epub 2012 Feb 8. Mol Genet Metab. 2012. PMID: 22402327 Free PMC article.

10

Mannose 6-phosphate conjugation is not sufficient to allow induction of immune tolerance to phenylalanine ammonia-lyase in dogs.

Vera M, Lester T, Zhao B, Tiger P, Clarke S, Tippin BL, Passage MB, Le SQ, Femenia J, Lemontt JF, Kakkis ED, Dickson PI. Vera M, et al. Among authors: le sq. JIMD Rep. 2013;8:63-72. doi: 10.1007/8904_2012_162. Epub 2012 Jul 6. JIMD Rep. 2013. PMID: 23430522 Free PMC article.

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