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Page 1
Depletion of antibiotic targets has widely varying effects on growth.
Wei JR, Krishnamoorthy V, Murphy K, Kim JH, Schnappinger D, Alber T, Sassetti CM, Rhee KY, Rubin EJ. Wei JR, et al. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4176-81. doi: 10.1073/pnas.1018301108. Epub 2011 Feb 22. Proc Natl Acad Sci U S A. 2011. PMID: 21368134 Free PMC article.
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis.
Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE 3rd, Sherman DR, Parish T, Sacchettini JC. Ioerger TR, et al. Among authors: murphy kc. PLoS One. 2013 Sep 23;8(9):e75245. doi: 10.1371/journal.pone.0075245. eCollection 2013. PLoS One. 2013. PMID: 24086479 Free PMC article.
Subpolar addition of new cell wall is directed by DivIVA in mycobacteria.
Meniche X, Otten R, Siegrist MS, Baer CE, Murphy KC, Bertozzi CR, Sassetti CM. Meniche X, et al. Among authors: murphy kc. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3243-51. doi: 10.1073/pnas.1402158111. Epub 2014 Jul 21. Proc Natl Acad Sci U S A. 2014. PMID: 25049412 Free PMC article.
Mycobacterial recombineering.
Murphy KC, Papavinasasundaram K, Sassetti CM. Murphy KC, et al. Methods Mol Biol. 2015;1285:177-99. doi: 10.1007/978-1-4939-2450-9_10. Methods Mol Biol. 2015. PMID: 25779316
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.
Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT. Johnson EO, et al. Among authors: murphy kc. Nature. 2019 Jul;571(7763):72-78. doi: 10.1038/s41586-019-1315-z. Epub 2019 Jun 19. Nature. 2019. PMID: 31217586
The structure of the endogenous ESX-3 secretion system.
Poweleit N, Czudnochowski N, Nakagawa R, Trinidad DD, Murphy KC, Sassetti CM, Rosenberg OS. Poweleit N, et al. Among authors: murphy kc. Elife. 2019 Dec 30;8:e52983. doi: 10.7554/eLife.52983. Elife. 2019. PMID: 31886769 Free PMC article.
A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response.
Sutiwisesak R, Hicks ND, Boyce S, Murphy KC, Papavinasasundaram K, Carpenter SM, Boucau J, Joshi N, Le Gall S, Fortune SM, Sassetti CM, Behar SM. Sutiwisesak R, et al. Among authors: murphy kc. PLoS Pathog. 2020 Oct 19;16(10):e1009000. doi: 10.1371/journal.ppat.1009000. eCollection 2020 Oct. PLoS Pathog. 2020. PMID: 33075106 Free PMC article.
263 results