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Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, Barrett LB, Ferreirós N, Naylor A, Penninger JM, Tegeder I, Zhong J, Blagg J, Channon KM, Johnsson K, Costigan M, Woolf CJ. Latremoliere A, et al. Among authors: costigan m. Neuron. 2015 Jun 17;86(6):1393-406. doi: 10.1016/j.neuron.2015.05.033. Neuron. 2015. PMID: 26087165 Free PMC article.
GCH1, BH4 and pain.
Latremoliere A, Costigan M. Latremoliere A, et al. Among authors: costigan m. Curr Pharm Biotechnol. 2011 Oct;12(10):1728-41. doi: 10.2174/138920111798357393. Curr Pharm Biotechnol. 2011. PMID: 21466440 Free PMC article. Review.
Analgesia by inhibiting tetrahydrobiopterin synthesis.
Costigan M, Latremoliere A, Woolf CJ. Costigan M, et al. Curr Opin Pharmacol. 2012 Feb;12(1):92-9. doi: 10.1016/j.coph.2011.10.019. Epub 2011 Dec 15. Curr Opin Pharmacol. 2012. PMID: 22178186 Free PMC article. Review.
Combining Human and Rodent Genetics to Identify New Analgesics.
Latremoliere A, Costigan M. Latremoliere A, et al. Among authors: costigan m. Neurosci Bull. 2018 Feb;34(1):143-155. doi: 10.1007/s12264-017-0152-z. Epub 2017 Jul 1. Neurosci Bull. 2018. PMID: 28667479 Free PMC article. Review.
Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice.
Fujita M, Scheffer DDL, Turnes BL, Cronin SJF, Latrémolière A, Costigan M, Woolf CJ, Latini A, Andrews NA. Fujita M, et al. Among authors: costigan m. Arthritis Rheumatol. 2020 Jan;72(1):57-66. doi: 10.1002/art.41060. Epub 2019 Nov 28. Arthritis Rheumatol. 2020. PMID: 31350812 Free PMC article.
Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer.
Cronin SJF, Rao S, Tejada MA, Turnes BL, Licht-Mayer S, Omura T, Brenneis C, Jacobs E, Barrett L, Latremoliere A, Andrews N, Channon KM, Latini A, Arvanites AC, Davidow LS, Costigan M, Rubin LL, Penninger JM, Woolf CJ. Cronin SJF, et al. Among authors: costigan m. Sci Transl Med. 2022 Aug 31;14(660):eabj1531. doi: 10.1126/scitranslmed.abj1531. Epub 2022 Aug 31. Sci Transl Med. 2022. PMID: 36044597 Free PMC article.
GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
Antoniades C, Shirodaria C, Van Assche T, Cunnington C, Tegeder I, Lötsch J, Guzik TJ, Leeson P, Diesch J, Tousoulis D, Stefanadis C, Costigan M, Woolf CJ, Alp NJ, Channon KM. Antoniades C, et al. Among authors: costigan m. J Am Coll Cardiol. 2008 Jul 8;52(2):158-65. doi: 10.1016/j.jacc.2007.12.062. J Am Coll Cardiol. 2008. PMID: 18598896 Free PMC article.
Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.
Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Omura T, et al. Among authors: costigan m. Neuron. 2015 Jun 3;86(5):1215-27. doi: 10.1016/j.neuron.2015.05.005. Epub 2015 May 21. Neuron. 2015. PMID: 26004914 Free PMC article.
Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling.
Cobos EJ, Nickerson CA, Gao F, Chandran V, Bravo-Caparrós I, González-Cano R, Riva P, Andrews NA, Latremoliere A, Seehus CR, Perazzoli G, Nieto FR, Joller N, Painter MW, Ma CHE, Omura T, Chesler EJ, Geschwind DH, Coppola G, Rangachari M, Woolf CJ, Costigan M. Cobos EJ, et al. Among authors: costigan m. Cell Rep. 2018 Jan 30;22(5):1301-1312. doi: 10.1016/j.celrep.2018.01.006. Cell Rep. 2018. PMID: 29386116 Free PMC article.
103 results