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Considerations for assessing the potential effects of antidiabetes drugs on cardiac ventricular repolarization: A report from the Cardiac Safety Research Consortium.
Heller S, Darpö B, Mitchell MI, Linnebjerg H, Leishman DJ, Mehrotra N, Zhu H, Koerner J, Fiszman ML, Balakrishnan S, Xiao S, Todaro TG, Hensley I, Guth BD, Michelson EL, Sager P. Heller S, et al. Among authors: koerner j. Am Heart J. 2015 Jul;170(1):23-35. doi: 10.1016/j.ahj.2015.03.007. Epub 2015 Mar 18. Am Heart J. 2015. PMID: 26093861 Review.
International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes.
Bass AS, Darpo B, Breidenbach A, Bruse K, Feldman HS, Garnes D, Hammond T, Haverkamp W, January C, Koerner J, Lawrence C, Leishman D, Roden D, Valentin JP, Vos MA, Zhou YY, Karluss T, Sager P. Bass AS, et al. Among authors: koerner j. Br J Pharmacol. 2008 Aug;154(7):1491-501. doi: 10.1038/bjp.2008.279. Br J Pharmacol. 2008. PMID: 18663380 Free PMC article.
The impact of drug-related QT prolongation on FDA regulatory decisions.
Park E, Willard J, Bi D, Fiszman M, Kozeli D, Koerner J. Park E, et al. Among authors: koerner j. Int J Cardiol. 2013 Oct 12;168(5):4975-6. doi: 10.1016/j.ijcard.2013.07.136. Epub 2013 Aug 3. Int J Cardiol. 2013. PMID: 23920061 No abstract available.
The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium.
Guth BD, Chiang AY, Doyle J, Engwall MJ, Guillon JM, Hoffmann P, Koerner J, Mittelstadt S, Ottinger S, Pierson JB, Pugsley MK, Rossman EI, Walisser J, Sarazan RD. Guth BD, et al. Among authors: koerner j. J Pharmacol Toxicol Methods. 2015 Sep-Oct;75:70-90. doi: 10.1016/j.vascn.2015.02.002. Epub 2015 Apr 3. J Pharmacol Toxicol Methods. 2015. PMID: 25843226 Free article.
The Diplomate in Safety Pharmacology (DSP) certification scheme.
Authier S, Curtis MJ, Soloviev M, Redfern WS, Kallman MJ, Hamlin RL, Leishman DJ, Valentin JP, Koerner JE, Vargas HM, Botchway A, Correll K, Pugsley MK. Authier S, et al. Among authors: koerner je. J Pharmacol Toxicol Methods. 2015 Sep-Oct;75:1-4. doi: 10.1016/j.vascn.2015.04.008. Epub 2015 May 8. J Pharmacol Toxicol Methods. 2015. PMID: 25959882
A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm.
Fermini B, Hancox JC, Abi-Gerges N, Bridgland-Taylor M, Chaudhary KW, Colatsky T, Correll K, Crumb W, Damiano B, Erdemli G, Gintant G, Imredy J, Koerner J, Kramer J, Levesque P, Li Z, Lindqvist A, Obejero-Paz CA, Rampe D, Sawada K, Strauss DG, Vandenberg JI. Fermini B, et al. Among authors: koerner j. J Biomol Screen. 2016 Jan;21(1):1-11. doi: 10.1177/1087057115594589. Epub 2015 Jul 13. J Biomol Screen. 2016. PMID: 26170255 Review.
An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs.
Pugsley MK, Guth B, Chiang AY, Doyle JM, Engwall M, Guillon JM, Hoffmann PK, Koerner JE, Mittelstadt SW, Pierson JB, Rossman EI, Sarazan DR, Parish ST. Pugsley MK, et al. J Pharmacol Toxicol Methods. 2017 May-Jun;85:1-21. doi: 10.1016/j.vascn.2017.01.002. Epub 2017 Jan 5. J Pharmacol Toxicol Methods. 2017. PMID: 28065821 Free article.
Proarrhythmia liability assessment and the comprehensive in vitro Proarrhythmia Assay (CiPA): An industry survey on current practice.
Authier S, Pugsley MK, Koerner JE, Fermini B, Redfern WS, Valentin JP, Vargas HM, Leishman DJ, Correll K, Curtis MJ. Authier S, et al. Among authors: koerner je. J Pharmacol Toxicol Methods. 2017 Jul;86:34-43. doi: 10.1016/j.vascn.2017.02.021. Epub 2017 Feb 20. J Pharmacol Toxicol Methods. 2017. PMID: 28223123 Free article.
An overview of the safety pharmacology society strategic plan.
Pugsley MK, Authier S, Koerner JE, Redfern WS, Markgraf CG, Brabham T, Correll K, Soloviev MV, Botchway A, Engwall M, Traebert M, Valentin JP, Mow TJ, Greiter-Wilke A, Leishman DJ, Vargas HM. Pugsley MK, et al. Among authors: koerner je. J Pharmacol Toxicol Methods. 2018 Sep-Oct;93:35-45. doi: 10.1016/j.vascn.2018.01.001. Epub 2018 Jan 9. J Pharmacol Toxicol Methods. 2018. PMID: 29330132 Review.
281 results