Medema RH - Search Results

1

The core spliceosome as target and effector of non-canonical ATM signalling.

Tresini M, Warmerdam DO, Kolovos P, Snijder L, Vrouwe MG, Demmers JA, van IJcken WF, Grosveld FG, Medema RH, Hoeijmakers JH, Mullenders LH, Vermeulen W, Marteijn JA. Tresini M, et al. Among authors: medema rh. Nature. 2015 Jul 2;523(7558):53-8. doi: 10.1038/nature14512. Epub 2015 Jun 24. Nature. 2015. PMID: 26106861 Free PMC article.

2

Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion.

van Vugt MA, Smits VA, Klompmaker R, Medema RH. van Vugt MA, et al. Among authors: medema rh. J Biol Chem. 2001 Nov 9;276(45):41656-60. doi: 10.1074/jbc.M101831200. Epub 2001 Aug 20. J Biol Chem. 2001. PMID: 11514540 Free article.

3

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.

Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM. Kops GJ, et al. Among authors: medema rh. Nature. 2002 Sep 19;419(6904):316-21. doi: 10.1038/nature01036. Nature. 2002. PMID: 12239572

4

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.

Macůrek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH. Macůrek L, et al. Among authors: medema rh. Nature. 2008 Sep 4;455(7209):119-23. doi: 10.1038/nature07185. Epub 2008 Jul 9. Nature. 2008. PMID: 18615013

5

Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.

Macůrek L, Lindqvist A, Voets O, Kool J, Vos HR, Medema RH. Macůrek L, et al. Among authors: medema rh. Oncogene. 2010 Apr 15;29(15):2281-91. doi: 10.1038/onc.2009.501. Epub 2010 Jan 25. Oncogene. 2010. PMID: 20101220

6

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis.

Saurin AT, van der Waal MS, Medema RH, Lens SM, Kops GJ. Saurin AT, et al. Among authors: medema rh. Nat Commun. 2011;2:316. doi: 10.1038/ncomms1319. Nat Commun. 2011. PMID: 21587233 Free PMC article.

7

UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway.

Warmerdam DO, Brinkman EK, Marteijn JA, Medema RH, Kanaar R, Smits VA. Warmerdam DO, et al. Among authors: medema rh. J Cell Sci. 2013 May 1;126(Pt 9):1923-30. doi: 10.1242/jcs.118265. Epub 2013 Feb 27. J Cell Sci. 2013. PMID: 23447674 Free article.

8

Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats.

Warmerdam DO, van den Berg J, Medema RH. Warmerdam DO, et al. Among authors: medema rh. Cell Rep. 2016 Mar 22;14(11):2519-27. doi: 10.1016/j.celrep.2016.02.048. Epub 2016 Mar 10. Cell Rep. 2016. PMID: 26972008 Free article.

9

Hypersensitivity to DNA damage in antephase as a safeguard for genome stability.

Feringa FM, Krenning L, Koch A, van den Berg J, van den Broek B, Jalink K, Medema RH. Feringa FM, et al. Among authors: medema rh. Nat Commun. 2016 Aug 26;7:12618. doi: 10.1038/ncomms12618. Nat Commun. 2016. PMID: 27561326 Free PMC article.

10

Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation.

Halim VA, García-Santisteban I, Warmerdam DO, van den Broek B, Heck AJR, Mohammed S, Medema RH. Halim VA, et al. Among authors: medema rh. Mol Cell Proteomics. 2018 Dec;17(12):2297-2308. doi: 10.1074/mcp.RA118.000652. Epub 2018 Feb 8. Mol Cell Proteomics. 2018. PMID: 29438997 Free PMC article.

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