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Covalent-Allosteric Kinase Inhibitors.
Weisner J, Gontla R, van der Westhuizen L, Oeck S, Ketzer J, Janning P, Richters A, Mühlenberg T, Fang Z, Taher A, Jendrossek V, Pelly SC, Bauer S, van Otterlo WA, Rauh D. Weisner J, et al. Among authors: bauer s. Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10313-6. doi: 10.1002/anie.201502142. Epub 2015 Jun 25. Angew Chem Int Ed Engl. 2015. PMID: 26110718
Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cells.
Bauer S, Parry JA, Mühlenberg T, Brown MF, Seneviratne D, Chatterjee P, Chin A, Rubin BP, Kuan SF, Fletcher JA, Duensing S, Duensing A. Bauer S, et al. Cancer Res. 2010 Jan 1;70(1):150-9. doi: 10.1158/0008-5472.CAN-09-1449. Epub 2009 Dec 22. Cancer Res. 2010. PMID: 20028860 Free PMC article.
p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors.
Henze J, Mühlenberg T, Simon S, Grabellus F, Rubin B, Taeger G, Schuler M, Treckmann J, Debiec-Rychter M, Taguchi T, Fletcher JA, Bauer S. Henze J, et al. Among authors: bauer s. PLoS One. 2012;7(5):e37776. doi: 10.1371/journal.pone.0037776. Epub 2012 May 25. PLoS One. 2012. PMID: 22662219 Free PMC article.
DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors.
Simon S, Grabellus F, Ferrera L, Galietta L, Schwindenhammer B, Mühlenberg T, Taeger G, Eilers G, Treckmann J, Breitenbuecher F, Schuler M, Taguchi T, Fletcher JA, Bauer S. Simon S, et al. Among authors: bauer s. Cancer Res. 2013 Jun 15;73(12):3661-70. doi: 10.1158/0008-5472.CAN-12-3839. Epub 2013 Apr 10. Cancer Res. 2013. PMID: 23576565 Free PMC article.
Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.
Garner AP, Gozgit JM, Anjum R, Vodala S, Schrock A, Zhou T, Serrano C, Eilers G, Zhu M, Ketzer J, Wardwell S, Ning Y, Song Y, Kohlmann A, Wang F, Clackson T, Heinrich MC, Fletcher JA, Bauer S, Rivera VM. Garner AP, et al. Among authors: bauer s. Clin Cancer Res. 2014 Nov 15;20(22):5745-5755. doi: 10.1158/1078-0432.CCR-14-1397. Epub 2014 Sep 19. Clin Cancer Res. 2014. PMID: 25239608 Free PMC article.
Inhibitor of Apoptosis Proteins (IAPs) are commonly dysregulated in GIST and can be pharmacologically targeted to enhance the pro-apoptotic activity of imatinib.
Falkenhorst J, Grunewald S, Mühlenberg T, Marino-Enriquez A, Reis AC, Corless C, Heinrich M, Treckmann J, Podleska LE, Schuler M, Fletcher JA, Bauer S. Falkenhorst J, et al. Among authors: bauer s. Oncotarget. 2016 Jul 5;7(27):41390-41403. doi: 10.18632/oncotarget.9159. Oncotarget. 2016. PMID: 27167336 Free PMC article.
2,606 results