Sohl CD - Search Results

1

Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ.

Sohl CD, Szymanski MR, Mislak AC, Shumate CK, Amiralaei S, Schinazi RF, Anderson KS, Yin YW. Sohl CD, et al. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8596-601. doi: 10.1073/pnas.1421733112. Epub 2015 Jun 29. Proc Natl Acad Sci U S A. 2015. PMID: 26124101 Free PMC article.

2

Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.

Sohl CD, Kasiviswanathan R, Kim J, Pradere U, Schinazi RF, Copeland WC, Mitsuya H, Baba M, Anderson KS. Sohl CD, et al. Mol Pharmacol. 2012 Jul;82(1):125-33. doi: 10.1124/mol.112.078758. Epub 2012 Apr 18. Mol Pharmacol. 2012. PMID: 22513406 Free PMC article.

3

Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.

Sohl CD, Kasiviswanathan R, Copeland WC, Anderson KS. Sohl CD, et al. Hum Mol Genet. 2013 Mar 15;22(6):1074-85. doi: 10.1093/hmg/dds509. Epub 2012 Dec 3. Hum Mol Genet. 2013. PMID: 23208208 Free PMC article.

4

Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kinetics.

Muftuoglu Y, Sohl CD, Mislak AC, Mitsuya H, Sarafianos SG, Anderson KS. Muftuoglu Y, et al. Among authors: sohl cd. Antiviral Res. 2014 Jun;106:1-4. doi: 10.1016/j.antiviral.2014.03.001. Epub 2014 Mar 12. Antiviral Res. 2014. PMID: 24632447 Free PMC article.

5

Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity.

Sohl CD, Singh K, Kasiviswanathan R, Copeland WC, Mitsuya H, Sarafianos SG, Anderson KS. Sohl CD, et al. Antimicrob Agents Chemother. 2012 Mar;56(3):1630-4. doi: 10.1128/AAC.05729-11. Epub 2011 Dec 12. Antimicrob Agents Chemother. 2012. PMID: 22155823 Free PMC article.

6

Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection.

Towle-Weicksel JB, Dalal S, Sohl CD, Doublié S, Anderson KS, Sweasy JB. Towle-Weicksel JB, et al. Among authors: sohl cd. J Biol Chem. 2014 Jun 6;289(23):16541-50. doi: 10.1074/jbc.M114.561878. Epub 2014 Apr 24. J Biol Chem. 2014. PMID: 24764311 Free PMC article.

7

Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy.

Sohl CD, Ryan MR, Luo B, Frey KM, Anderson KS. Sohl CD, et al. ACS Chem Biol. 2015 May 15;10(5):1319-29. doi: 10.1021/acschembio.5b00014. Epub 2015 Feb 24. ACS Chem Biol. 2015. PMID: 25686244 Free PMC article.

8

The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT.

Ryan MR, Sohl CD, Luo B, Anderson KS. Ryan MR, et al. Among authors: sohl cd. Mol Cancer Res. 2019 Feb;17(2):532-543. doi: 10.1158/1541-7786.MCR-18-0429. Epub 2018 Sep 26. Mol Cancer Res. 2019. PMID: 30257990 Free PMC article.

9

Pools and Pols: Mechanism of a mutator phenotype.

Sohl CD, Ray S, Sweasy JB. Sohl CD, et al. Proc Natl Acad Sci U S A. 2015 May 12;112(19):5864-5. doi: 10.1073/pnas.1505169112. Epub 2015 Apr 30. Proc Natl Acad Sci U S A. 2015. PMID: 25931524 Free PMC article. No abstract available.

10

Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding.

Sohl CD, Isin EM, Eoff RL, Marsch GA, Stec DF, Guengerich FP. Sohl CD, et al. J Biol Chem. 2008 Mar 14;283(11):7293-308. doi: 10.1074/jbc.M709783200. Epub 2008 Jan 10. J Biol Chem. 2008. PMID: 18187423 Free article.

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