Garcin ED - Search Results

1

Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation.

Sarkar A, Dai Y, Haque MM, Seeger F, Ghosh A, Garcin ED, Montfort WR, Hazen SL, Misra S, Stuehr DJ. Sarkar A, et al. Among authors: garcin ed. J Biol Chem. 2015 Aug 28;290(35):21615-28. doi: 10.1074/jbc.M115.645515. Epub 2015 Jul 1. J Biol Chem. 2015. PMID: 26134567 Free PMC article.

2

Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer.

Guan ZW, Haque MM, Wei CC, Garcin ED, Getzoff ED, Stuehr DJ. Guan ZW, et al. Among authors: garcin ed. J Biol Chem. 2010 Jan 29;285(5):3064-75. doi: 10.1074/jbc.M109.000810. Epub 2009 Nov 30. J Biol Chem. 2010. PMID: 19948738 Free PMC article.

3

The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation.

Wei CC, Wang ZQ, Durra D, Hemann C, Hille R, Garcin ED, Getzoff ED, Stuehr DJ. Wei CC, et al. Among authors: garcin ed. J Biol Chem. 2005 Mar 11;280(10):8929-35. doi: 10.1074/jbc.M409737200. Epub 2005 Jan 4. J Biol Chem. 2005. PMID: 15632185 Free article.

4

C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase.

Tiso M, Konas DW, Panda K, Garcin ED, Sharma M, Getzoff ED, Stuehr DJ. Tiso M, et al. Among authors: garcin ed. J Biol Chem. 2005 Nov 25;280(47):39208-19. doi: 10.1074/jbc.M507775200. Epub 2005 Sep 8. J Biol Chem. 2005. PMID: 16150731 Free article.

5

Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.

Seeger F, Quintyn R, Tanimoto A, Williams GJ, Tainer JA, Wysocki VH, Garcin ED. Seeger F, et al. Among authors: garcin ed. Biochemistry. 2014 Apr 8;53(13):2153-65. doi: 10.1021/bi500129k. Epub 2014 Mar 26. Biochemistry. 2014. PMID: 24669844 Free PMC article.

6

Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.

Rogers NM, Seeger F, Garcin ED, Roberts DD, Isenberg JS. Rogers NM, et al. Among authors: garcin ed. Front Physiol. 2014 Apr 4;5:134. doi: 10.3389/fphys.2014.00134. eCollection 2014. Front Physiol. 2014. PMID: 24772092 Free PMC article. Review.

7

YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit.

Purohit R, Fritz BG, The J, Issaian A, Weichsel A, David CL, Campbell E, Hausrath AC, Rassouli-Taylor L, Garcin ED, Gage MJ, Montfort WR. Purohit R, et al. Among authors: garcin ed. Biochemistry. 2014 Jan 14;53(1):101-14. doi: 10.1021/bi4015133. Epub 2013 Dec 30. Biochemistry. 2014. PMID: 24328155 Free PMC article.

8

Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.

Garcin ED, Bruns CM, Lloyd SJ, Hosfield DJ, Tiso M, Gachhui R, Stuehr DJ, Tainer JA, Getzoff ED. Garcin ED, et al. J Biol Chem. 2004 Sep 3;279(36):37918-27. doi: 10.1074/jbc.M406204200. Epub 2004 Jun 17. J Biol Chem. 2004. PMID: 15208315 Free article.

9

Synergistic mutations in soluble guanylyl cyclase (sGC) reveal a key role for interfacial regions in the sGC activation mechanism.

Childers KC, Yao XQ, Giannakoulias S, Amason J, Hamelberg D, Garcin ED. Childers KC, et al. Among authors: garcin ed. J Biol Chem. 2019 Nov 29;294(48):18451-18464. doi: 10.1074/jbc.RA119.011010. Epub 2019 Oct 23. J Biol Chem. 2019. PMID: 31645439 Free PMC article.

10

Structure/function of the soluble guanylyl cyclase catalytic domain.

Childers KC, Garcin ED. Childers KC, et al. Among authors: garcin ed. Nitric Oxide. 2018 Jul 1;77:53-64. doi: 10.1016/j.niox.2018.04.008. Epub 2018 Apr 25. Nitric Oxide. 2018. PMID: 29702251 Free PMC article. Review.

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