Kay LE - Search Results

1

FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing.

Wang Z, Dove P, Wang X, Shamas-Din A, Li Z, Nachman A, Oh YJ, Hurren R, Ruschak A, Climie S, Press B, Griffin C, Undzys E, Aman A, Al-awar R, Kay LE, O'Neill D, Trudel S, Slassi M, Schimmer AD. Wang Z, et al. Among authors: kay le. Cell Death Dis. 2015 Jul 9;6(7):e1815. doi: 10.1038/cddis.2015.187. Cell Death Dis. 2015. PMID: 26158521 Free PMC article.

2

TROSY-based NMR evidence for a novel class of 20S proteasome inhibitors.

Sprangers R, Li X, Mao X, Rubinstein JL, Schimmer AD, Kay LE. Sprangers R, et al. Among authors: kay le. Biochemistry. 2008 Jul 1;47(26):6727-34. doi: 10.1021/bi8005913. Epub 2008 Jun 10. Biochemistry. 2008. PMID: 18540636

3

Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma.

Mao X, Li X, Sprangers R, Wang X, Venugopal A, Wood T, Zhang Y, Kuntz DA, Coe E, Trudel S, Rose D, Batey RA, Kay LE, Schimmer AD. Mao X, et al. Among authors: kay le. Leukemia. 2009 Mar;23(3):585-90. doi: 10.1038/leu.2008.232. Epub 2008 Aug 28. Leukemia. 2009. PMID: 18754030 No abstract available.

4

Methyl groups as probes of supra-molecular structure, dynamics and function.

Ruschak AM, Kay LE. Ruschak AM, et al. Among authors: kay le. J Biomol NMR. 2010 Jan;46(1):75-87. doi: 10.1007/s10858-009-9376-1. Epub 2009 Sep 27. J Biomol NMR. 2010. PMID: 19784810 Review.

5

Effect of noncompetitive proteasome inhibition on bortezomib resistance.

Li X, Wood TE, Sprangers R, Jansen G, Franke NE, Mao X, Wang X, Zhang Y, Verbrugge SE, Adomat H, Li ZH, Trudel S, Chen C, Religa TL, Jamal N, Messner H, Cloos J, Rose DR, Navon A, Guns E, Batey RA, Kay LE, Schimmer AD. Li X, et al. Among authors: kay le. J Natl Cancer Inst. 2010 Jul 21;102(14):1069-82. doi: 10.1093/jnci/djq198. Epub 2010 May 26. J Natl Cancer Inst. 2010. PMID: 20505154

6

The proteasome antechamber maintains substrates in an unfolded state.

Ruschak AM, Religa TL, Breuer S, Witt S, Kay LE. Ruschak AM, et al. Among authors: kay le. Nature. 2010 Oct 14;467(7317):868-71. doi: 10.1038/nature09444. Nature. 2010. PMID: 20944750

7

A simple strategy for ¹³C, ¹H labeling at the Ile-γ2 methyl position in highly deuterated proteins.

Ruschak AM, Velyvis A, Kay LE. Ruschak AM, et al. Among authors: kay le. J Biomol NMR. 2010 Nov;48(3):129-35. doi: 10.1007/s10858-010-9449-1. Epub 2010 Oct 14. J Biomol NMR. 2010. PMID: 20949307

8

Site-directed methyl group labeling as an NMR probe of structure and dynamics in supramolecular protein systems: applications to the proteasome and to the ClpP protease.

Religa TL, Ruschak AM, Rosenzweig R, Kay LE. Religa TL, et al. Among authors: kay le. J Am Chem Soc. 2011 Jun 15;133(23):9063-8. doi: 10.1021/ja202259a. Epub 2011 May 20. J Am Chem Soc. 2011. PMID: 21557628

9

Novel proteasome inhibitors to overcome bortezomib resistance.

Ruschak AM, Slassi M, Kay LE, Schimmer AD. Ruschak AM, et al. Among authors: kay le. J Natl Cancer Inst. 2011 Jul 6;103(13):1007-17. doi: 10.1093/jnci/djr160. Epub 2011 May 23. J Natl Cancer Inst. 2011. PMID: 21606441 Review.

10

An economical method for production of (2)H, (13)CH3-threonine for solution NMR studies of large protein complexes: application to the 670 kDa proteasome.

Velyvis A, Ruschak AM, Kay LE. Velyvis A, et al. Among authors: kay le. PLoS One. 2012;7(9):e43725. doi: 10.1371/journal.pone.0043725. Epub 2012 Sep 11. PLoS One. 2012. PMID: 22984438 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

451 results

Search Page

Filters